G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Chemotherapy induces ATP release from tumor cells.
Isabelle Martins,Antoine Tesniere,Oliver Kepp,Mickaël Michaud,Frédéric Schlemmer,Laura Senovilla,Claire Séror,Didier Métivier,Jean-Luc Perfettini,Laurence Zitvogel,Guido Kroemer +10 more
TL;DR: It is described that multiple distinct anticancer drugs reduce the intracellular concentration of ATP before and during the manifestation of apoptotic characteristics such as the dissipation of the mitochondrial transmembrane potential and the exposure of phosphatidylserine residues on the plasma membrane.
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Vital functions for lethal caspases
TL;DR: The nonapoptotic functions of caspases implicate that cells can restrict the proteolytic activity of these enzymes to selected substrates, which is suspected to play a role in the pathophysiology of several human diseases.
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Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator
Helena L. A. Vieira,Delphine Haouzi,C El Hamel,Etienne Jacotot,A-S Belzacq,Catherine Brenner,Guido Kroemer +6 more
TL;DR: It is discussed that ANT has two opposite functions, on the one hand, ANT is a vital, specific antiporter which accounts for the exchange of ATP and ADP on IM, and on the other hand ANT can form a non-specific pore.
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Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
Lorenzo Galluzzi,José Manuel Bravo-San Pedro,José Manuel Bravo-San Pedro,José Manuel Bravo-San Pedro,Sandra Demaria,Silvia C. Formenti,Guido Kroemer +6 more
TL;DR: Accumulating preclinical and clinical evidence is discussed in support of the all-too-often dismissed possibility that activating autophagy might be a relevant clinical objective that enables an increase in the effectiveness of immunogenic chemotherapy and/or radiation therapy.
Journal Article
Mitochondrial permeability transition triggers lymphocyte apoptosis.
Philippe Marchetti,Tamara Hirsch,Naoufal Zamzami,Maria Castedo,Didier Decaudin,Santos A. Susin,B Masse,Guido Kroemer +7 more
TL;DR: Data from this work are compatible with the hypotheses that mitochondrial PT is self-sufficient to trigger apoptosis and that Bcl-2 may directly regulate PT.