G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
Papers
More filters
Journal ArticleDOI
Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis
Simone Fulda,Eric P. Meyer,Claudia Friesen,Santos A. Susin,Guido Kroemer,Klaus-Michael Debatin +5 more
TL;DR: The findings of a cell type specific response to cytotoxic drugs have implications for the identification of molecular parameters for chemosensitivity or resistance in different tumor cells.
Journal ArticleDOI
Clockophagy is a novel selective autophagy process favoring ferroptosis
Minghua Yang,Pan Chen,Jiao Liu,Shan Zhu,Shan Zhu,Guido Kroemer,Daniel J. Klionsky,Michael T. Lotze,Herbert J. Zeh,Rui Kang,Daolin Tang,Daolin Tang +11 more
TL;DR: Findings reveal a new pathway, initiated by the autophagic removal of ARNTL, that facilitates ferroptosis induction, and identifies SQSTM1 as a cargo receptor responsible for autophagy-dependent AR NTL degradation.
Journal ArticleDOI
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.
Slaven Stekovic,Sebastian J. Hofer,Norbert J. Tripolt,Miguel A. Aon,Philipp Royer,Lukas Pein,Julia T. Stadler,Julia T. Stadler,Tobias Pendl,Barbara Prietl,Jasmin Url,Sabrina Schroeder,Jelena Tadic,Tobias Eisenberg,Christoph Magnes,Michael Stumpe,Elmar Zuegner,Natalie Bordag,Regina Riedl,Albrecht Schmidt,Ewald Kolesnik,Nicolas Verheyen,Anna Springer,Tobias Madl,Frank Sinner,Frank Sinner,Rafael de Cabo,Guido Kroemer,Barbara Obermayer-Pietsch,Jörn Dengjel,Jörn Dengjel,Harald Sourij,Thomas R. Pieber,Thomas R. Pieber,Frank Madeo +34 more
TL;DR: It is shown that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average, and supports its safety.
Journal ArticleDOI
Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
Tobias Eisenberg,Sabrina Schroeder,Aleksandra Andryushkova,Tobias Pendl,Victoria Küttner,Anuradha Bhukel,Anuradha Bhukel,Guillermo Mariño,Guillermo Mariño,Guillermo Mariño,Federico Pietrocola,Federico Pietrocola,Federico Pietrocola,Alexandra Harger,Alexandra Harger,Andreas Zimmermann,Tarek Moustafa,Adrian Sprenger,Evelyne Jany,Sabrina Büttner,Didac Carmona-Gutierrez,Christoph Ruckenstuhl,Julia Ring,Wieland Reichelt,Katharina Schimmel,Tina Leeb,Claudia Moser,Stefanie Schatz,Lars P. Kamolz,Christoph Magnes,Frank Sinner,Frank Sinner,Simon Sedej,Kai-Uwe Fröhlich,Gábor Juhász,Thomas R. Pieber,Thomas R. Pieber,Jörn Dengjel,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +41 more
TL;DR: It is shown that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autophagy during aging in yeast, and brain-specific knockdown of Drosophila AcCoA synthetase was sufficient to enhance autophagic protein clearance and prolong lifespan.
Journal ArticleDOI
Trial watch: Oncolytic viruses for cancer therapy
Erika Vacchelli,Alexander M.M. Eggermont,Catherine Sautès-Fridman,Jérôme Galon,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +6 more
TL;DR: The latest advances in this active area of translational investigation are covered, summarizing high-impact studies that have been published during the last 12 months and discussing clinical trials that have be initiated in the same period to assess the therapeutic potential of oncolytic virotherapy in oncological indications.