G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Mitochondrial permeability transition in apoptosis and necrosis.
TL;DR: Cytofluorometric methods assessing the mitochondrial membrane function and structure can be employed to demonstrate that, at least in most models of apoptosis, mitochondrial changes precede caspase and nuclease activation.
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Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437
Anne-Sophie Belzacq,Chahrazed El Hamel,Helena L. A. Vieira,Isabel Cohen,Delphine Haouzi,Didier Métivier,Philippe Marchetti,Catherine Brenner,Catherine Brenner,Guido Kroemer +9 more
TL;DR: It is indicated that ANT is a target of lonidamine, arsenite, and CD437 and an unexpected heterogeneity in the mode of action of these three compounds is unraveled.
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Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis.
Antonio Macho,Didier Decaudin,Maria Castedo,Tamara Hirsch,Santos A. Susin,Naoufal Zamzami,Guido Kroemer +6 more
TL;DR: Chloromethyl-X-rosamine (CMXRos) is shown to be a viable alternative to other delta psi m-sensitive probes, and that it allows for formaldehyde fixation of cells before analysis, and provides several methodological advantages over other, nonfixable fluorochromes used forDelta psi m determination.
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Autophagy for tissue homeostasis and neuroprotection
TL;DR: The contribution of autophagic malfunctions to the development of several common neurological disorders and the potential benefits of pharmacologically induced autophagy for the avoidance of neurodegeneration are discussed.
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Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.
Inge Tinhofer,David Bernhard,Monika Senfter,Gabriele Anether,Markus Loeffler,Guido Kroemer,Reinhard Kofler,Adam Csordas,Richard Greil +8 more
TL;DR: Inhibition of ∆Ψm breakdown and of ROS generation by N‐acetylcysteine, or by overexpression of Bcl‐2 protein, prevented apoptosis induction by resveratrol.