Guido Kroemer

TL;DR: This work has identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery that contributes to the biogenesis of respiratory chain complexes and establishes an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis.

TL;DR: A non-canonical role for IRE1α as a scaffold that stabilizes InsP3Rs at MAMs to control calcium uptake, fine-tunes ER–mitochondrial communication and regulates energy metabolism via AMPK is uncovered.

TL;DR: Recombinant caspases were added to purified mitochondria and were found to affect the permeability of both mitochondrial membranes, suggesting that caspase and mitochondria can engage in a circular self‐amplification loop and accelerate the apoptosis process and/or coordinate the apoptotic response between different mitochondria within the same cell.

TL;DR: How Ca2+ participates in the exogenous and endogenous signals controlling cell proliferation, as well as in the mechanisms by which cells die if irreparable cell cycle damage occurs, is discussed.

TL;DR: Data now demonstrate that these organelles also regulate the innate immune response by modulating inflammasome-mediated generation of proinflammatory cytokines.