G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway.
Christophe Massard,Zermati Y,Anne-Laure Pauleau,Nathanael Larochette,Didier Métivier,Laure Sabatier,Guido Kroemer,J-C. Soria +7 more
TL;DR: In this article, the authors show that hTERT depletion has no adverse effects on the viability or proliferation of cervical and colon carcinoma cell lines, as evaluated within 72 h after transfection with hTERTs-specific small interfering RNAs (siRNAs).
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Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event.
Matthew G. Annis,Naoufal Zamzami,Weijia Zhu,Linda Z. Penn,Guido Kroemer,Brian Leber,David W. Andrews +6 more
TL;DR: In Rat-1 cells, a Bcl-2 mutant targeted exclusively to the endoplasmic reticulum (Bcl-cb5) was effective at inhibiting apoptosis induced by serum starvation/myc, or ceramide but not apoptosisinduced by etoposide.
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The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor?
Arielle Elkrief,Arielle Elkrief,Lisa Derosa,Lisa Derosa,Guido Kroemer,L. Zitvogel,L. Zitvogel,Bertrand Routy +7 more
TL;DR: This review summarizes recent publications addressing the impact of the gut microbiome on ICI efficacy, discusses currently available data on the effect of ATB administered in different time-frames respect to ICI initiation, and discusses the therapeutic implications of these findings.
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Pyroptosis - a cell death modality of its kind?
Oliver Kepp,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Guido Kroemer +7 more
TL;DR: The term “pyroptosis” was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase‐1 activation and hence leads to the release of pyrogenic interleukins.
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Caspase-dependent and caspase-independent cell death pathways in yeast.
Frank Madeo,Didac Carmona-Gutierrez,Julia Ring,Sabrina Büttner,Tobias Eisenberg,Guido Kroemer +5 more
TL;DR: Yeast constitutes an excellent model organism to delineate phylogenetically conserved pathways leading to apoptotic or necrotic cell death and can be used to identify pharmacological and genetic modulators of cell death pathways that are relevant for human disease.