G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Enlightening the impact of immunogenic cell death in photodynamic cancer therapy.
Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Oliver Kepp,Oliver Kepp,Oliver Kepp,Guido Kroemer +6 more
TL;DR: A signalling pathway is delineated that leads to calreticulin (CRT) exposure and ATP release by cancer cells that succumb to photodynamic therapy (PTD), thereby providing fresh insights into the molecular regulation of immunogenic cell death (ICD).
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Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study.
Simone Boehrer,Simone Boehrer,Simone Boehrer,Lionel Ades,Thorsten Braun,Thorsten Braun,Thorsten Braun,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Jennifer Grosjean,Jennifer Grosjean,Claire Fabre,Claire Fabre,Geneviève Le Roux,Claude Gardin,Antoine Martin,Stéphane de Botton,Pierre Fenaux,Guido Kroemer,Guido Kroemer,Guido Kroemer +21 more
TL;DR: Novel evidence is provided in vitro, ex vivo, and in vivo for the potential therapeutic efficacy of erlotinib in the treatment of high-risk MDS and AML.
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Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone
Jens Hoffmann,Ilio Vitale,Ilio Vitale,Bernd Buchmann,Lorenzo Galluzzi,Lorenzo Galluzzi,Wolfgang Schwede,Laura Senovilla,Laura Senovilla,Werner Skuballa,Sonia Vivet,Sonia Vivet,Rosemarie B. Lichtner,Jose Miguel Vicencio,Jose Miguel Vicencio,Theocharis Panaretakis,Gerhard Siemeister,Hermann Lage,Lisa Nanty,Lisa Nanty,Stefanie Hammer,Kevin Mittelstaedt,Sebastian Winsel,Sebastian Winsel,Julia Eschenbrenner,Julia Eschenbrenner,Maria Castedo,Maria Castedo,Carine Demarche,Ulrich Klar,Guido Kroemer,Guido Kroemer +31 more
TL;DR: Sagopilone is highly effective in reducing the growth of paclitaxel-resistant cancer cells and is more cytotoxic than other epothilones in a large panel of human cancer cell lines in vitro and in vivo.
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Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells: correlation with changes in mitochondria, glutathione depletion, intracellular acidification and caspase 3 activation.
Patrice X. Petit,Marie-Claude Gendron,Nicolas Schrantz,Didier Métivier,Guido Kroemer,Zofia Maciorowska,Franck Sureau,Steven K. Koester +7 more
TL;DR: There appears to be a close functional relationship between mitochondrial and cellular redox changes during early apoptosis; events that are inhibited by Bcl-2.
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The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer.
Christoph Ruckenstuhl,Sabrina Büttner,Didac Carmona-Gutierrez,Tobias Eisenberg,Guido Kroemer,Guido Kroemer,Guido Kroemer,Stephan J. Sigrist,Stephan J. Sigrist,Kai-Uwe Fröhlich,Frank Madeo +10 more
TL;DR: The Warburg effect might directly contribute to the initiation of cancer formation - not only by enhanced glycolysis - but also via decreased respiration in the presence of oxygen, which suppresses apoptosis.