Guido Reber

TL;DR: This document appraise the existing evidence on clinical and laboratory features of APS addressed during the forum and proposes amendments to the Sapporo criteria, including definitions on features ofAPS that were not included in the updated criteria.

TL;DR: Modalities for blood collection and processing are fully delineated and the choice of tests is limited to dRVVT and a sensitive aPTT and the interpretation of the results in general and in particular situations is reported.

TL;DR: Results show that a low concentration of plasma DD measured by the ELISA technique might be used to rule out VTE in clinically suspected patients, and the clinical usefulness of the DD ELISA test should now be assessed in management trials under routine conditions, in the frame of clinical decision-making diagnostic processes.

TL;DR: Plasma measurement of D-dimer (DD), a specific derivative of crosslinked fibrin, has a definite place in the diagnostic procedure for suspected acute pulmonary embolism in attenders at emergency departments: a concentration below 500 micrograms/l rules out the diagnosis.

TL;DR: In this paper, an ELISA was developed to detect anti-prothrombin autoantibodies in patient serum or plasma, but no or very low signal was observed using human prothromb immobilized on plain polystyrene plates, in the absence of added calcium and phospholipid.