Guido von Figura

TL;DR: It is suggested that ductal and stem-like centroacinar cells are surprisingly refractory to oncogenic transformation, whereas acinar cells readily form PDA precursor lesions with ductal features, and formation of acinar-derived premalignant lesions depends on ectopic induction of the ductal gene Sox9.

TL;DR: This review describes the application of luminol chemiluminescence in forensic, biomedical, and clinical sciences and provides information about different compounds that may enhance or inhibit the LCL along with the effect of pH and concentration on LCL.

TL;DR: This study implicates Brg1 as a determinant of context-dependent Kras-driven pancreatic tumorigenesis and suggests that chromatin remodelling may underlie the development of distinct PDA subsets.

TL;DR: Investigation of the influence of lifestyle factors on the aging‐associated expression of serum markers of DNA damage in comparison with other described markers of cellular aging in human peripheral blood shows that lifestyle factors have an age‐independent impact on the expression level of biomarkers ofDNA damage.

TL;DR: This study provides the first experimental evidence that telomerase gene mutations are present in patients developing cirrhosis as a consequence of chronic liver disease, and supports the concept that telomere shortening can represent a causal factor impairing liver regeneration and accelerating Cirrhosis formation in response to chronic Liver disease.