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Guilherme Veiga Guimarães

Bio: Guilherme Veiga Guimarães is an academic researcher from University of São Paulo. The author has contributed to research in topics: Heart failure & Heart rate. The author has an hindex of 31, co-authored 164 publications receiving 4037 citations. Previous affiliations of Guilherme Veiga Guimarães include Universidade Federal de Mato Grosso.


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240 citations

Journal ArticleDOI
TL;DR: A pratica regular de atividade fisica apresenta efeitos beneficos na prevencao e tratamento da hipertensao arterial, resistencia a insulina, diabetes, dislipidemia e obesidade, resultando em melhora da qualidade de vida.
Abstract: A pratica regular de atividade fisica tem sido recomendada para a prevencao e reabilitacao de doencas cardiovasculares e outras doencas cronicas por diferentes associacoes de saude no mundo, como o American College of Sports Medicine, os Centers for Disease Control and Prevention, a American Heart Association, o National Institutes of Health, o US Surgeon General, a Sociedade Brasileira de Cardiologia, entre outras. Estudos epidemiologicos tem demonstrado relacao direta entre inatividade fisica e a presenca de multiplos fatores de risco como os encontrados na sindrome metabolica. Entretanto, tem sido demonstrado que a pratica regular de exercicio fisico apresenta efeitos beneficos na prevencao e tratamento da hipertensao arterial, resistencia a insulina, diabetes, dislipidemia e obesidade. Com isso, o condicionamento fisico deve ser estimulado para todos, pessoas saudaveis e com multiplos fatores de risco, desde que sejam capazes de participar de um programa de treinamento fisico. Assim como a terapeutica clinica cuida de manter a funcao dos orgaos, a atividade fisica promove adaptacoes fisiologicas favoraveis, resultando em melhora da qualidade de vida.

239 citations

Journal ArticleDOI
TL;DR: Continuous and interval exercise training were beneficial for blood pressure control, but only interval training reduced arterial stiffness in treated hypertensive subjects.
Abstract: Effects of continuous vs. interval exercise training on blood pressure and arterial stiffness in treated hypertension

230 citations

Journal ArticleDOI
TL;DR: Exercise intensity was an important factor in improving cardiorespiratory fitness and reversing hemodynamic, metabolic and hormonal alterations involved in the pathophysiology of hypertension.
Abstract: Exercise training has an important role in the prevention and treatment of hypertension, but its effects on the early metabolic and hemodynamic abnormalities observed in normotensive offspring of hypertensive parents (FH+) have not been studied We compared high-intensity interval (aerobic interval training, AIT) and moderate-intensity continuous exercise training (CMT) with regard to hemodynamic, metabolic and hormonal variables in FH+ subjects Forty-four healthy FH+ women (250+/-44 years) randomized to control (ConFH+) or to a three times per week equal-volume AIT (80-90% of VO(2MAX)) or CMT (50-60% of VO(2MAX)) regimen, and 15 healthy women with normotensive parents (ConFH-; 253+/-31 years) had their hemodynamic, metabolic and hormonal variables analyzed at baseline and after 16 weeks of follow-up Ambulatorial blood pressure (ABP), glucose and cholesterol levels were similar among all groups, but the FH+ groups showed higher insulin, insulin sensitivity, carotid-femoral pulse wave velocity (PWV), norepinephrine and endothelin-1 (ET-1) levels and lower nitrite/nitrate (NOx) levels than ConFH- subjects AIT and CMT were equally effective in improving ABP (P<005), insulin and insulin sensitivity (P<0001); however, AIT was superior in improving cardiorespiratory fitness (15 vs 8%; P<005), PWV (P<001), and BP, norepinephrine, ET-1 and NOx response to exercise (P<005) Exercise intensity was an important factor in improving cardiorespiratory fitness and reversing hemodynamic, metabolic and hormonal alterations involved in the pathophysiology of hypertension These findings may have important implications for the exercise training programs used for the prevention of inherited hypertensive disorder

217 citations


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TL;DR: The recommended quantity and quality of exercise for developing and maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in healthy adults is discussed in the position stand of the American College of Sports Medicine (ACSM) Position Stand.
Abstract: The purpose of this Position Stand is to provide guidance to professionals who counsel and prescribe individualized exercise to apparently healthy adults of all ages. These recommendations also may apply to adults with certain chronic diseases or disabilities, when appropriately evaluated and advised by a health professional. This document supersedes the 1998 American College of Sports Medicine (ACSM) Position Stand, "The Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Healthy Adults." The scientific evidence demonstrating the beneficial effects of exercise is indisputable, and the benefits of exercise far outweigh the risks in most adults. A program of regular exercise that includes cardiorespiratory, resistance, flexibility, and neuromotor exercise training beyond activities of daily living to improve and maintain physical fitness and health is essential for most adults. The ACSM recommends that most adults engage in moderate-intensity cardiorespiratory exercise training for ≥30 min·d on ≥5 d·wk for a total of ≥150 min·wk, vigorous-intensity cardiorespiratory exercise training for ≥20 min·d on ≥3 d·wk (≥75 min·wk), or a combination of moderate- and vigorous-intensity exercise to achieve a total energy expenditure of ≥500-1000 MET·min·wk. On 2-3 d·wk, adults should also perform resistance exercises for each of the major muscle groups, and neuromotor exercise involving balance, agility, and coordination. Crucial to maintaining joint range of movement, completing a series of flexibility exercises for each the major muscle-tendon groups (a total of 60 s per exercise) on ≥2 d·wk is recommended. The exercise program should be modified according to an individual's habitual physical activity, physical function, health status, exercise responses, and stated goals. Adults who are unable or unwilling to meet the exercise targets outlined here still can benefit from engaging in amounts of exercise less than recommended. In addition to exercising regularly, there are health benefits in concurrently reducing total time engaged in sedentary pursuits and also by interspersing frequent, short bouts of standing and physical activity between periods of sedentary activity, even in physically active adults. Behaviorally based exercise interventions, the use of behavior change strategies, supervision by an experienced fitness instructor, and exercise that is pleasant and enjoyable can improve adoption and adherence to prescribed exercise programs. Educating adults about and screening for signs and symptoms of CHD and gradual progression of exercise intensity and volume may reduce the risks of exercise. Consultations with a medical professional and diagnostic exercise testing for CHD are useful when clinically indicated but are not recommended for universal screening to enhance the safety of exercise.

7,223 citations

Journal ArticleDOI
01 Apr 2017
TL;DR: In this article, the authors focus on the global epidemiology of heart failure, providing data about prevalence, incidence, mortality and morbidity worldwide, and show geographic variations, depending on the different aetiologies and clinical characteristics observed among patients with heart failure.
Abstract: Heart failure (HF) is a global pandemic affecting at least 26 million people worldwide and is increasing in prevalence. HF health expenditures are considerable and will increase dramatically with an ageing population. Despite the significant advances in therapies and prevention, mortality and morbidity are still high and quality of life poor. The prevalence, incidence, mortality and morbidity rates reported show geographic variations, depending on the different aetiologies and clinical characteristics observed among patients with HF. In this review we focus on the global epidemiology of HF, providing data about prevalence, incidence, mortality and morbidity worldwide.

1,572 citations

Journal Article
TL;DR: This study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.
Abstract: Aims Carotid–femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as a routine tool for clinical patient evaluation has been hampered by the absence of reference values. The aim of the present study is to establish reference and normal values for PWV based on a large European population. Methods and results We gathered data from 16 867 subjects and patients from 13 different centres across eight European countries, in which PWV and basic clinical parameters were measured. Of these, 11 092 individuals were free from overt CV disease, non-diabetic and untreated by either anti-hypertensive or lipid-lowering drugs and constituted the reference value population, of which the subset with optimal/normal blood pressures (BPs) (n = 1455) is the normal value population. Prior to data pooling, PWV values were converted to a common standard using established conversion formulae. Subjects were categorized by age decade and further subdivided according to BP categories. Pulse wave velocity increased with age and BP category; the increase with age being more pronounced for higher BP categories and the increase with BP being more important for older subjects. The distribution of PWV with age and BP category is described and reference values for PWV are established. Normal values are proposed based on the PWV values observed in the non-hypertensive subpopulation who had no additional CV risk factors. Conclusion The present study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.

1,371 citations

Journal ArticleDOI
TL;DR: The addition of CRF for risk classification presents health professionals with unique opportunities to improve patient management and to encourage lifestyle-based strategies designed to reduce cardiovascular risk to meet the American Heart Association’s 2020 goals.
Abstract: Mounting evidence has firmly established that low levels of cardiorespiratory fitness (CRF) are associated with a high risk of cardiovascular disease, all-cause mortality, and mortality rates attributable to various cancers. A growing body of epidemiological and clinical evidence demonstrates not only that CRF is a potentially stronger predictor of mortality than established risk factors such as smoking, hypertension, high cholesterol, and type 2 diabetes mellitus, but that the addition of CRF to traditional risk factors significantly improves the reclassification of risk for adverse outcomes. The purpose of this statement is to review current knowledge related to the association between CRF and health outcomes, increase awareness of the added value of CRF to improve risk prediction, and suggest future directions in research. Although the statement is not intended to be a comprehensive review, critical references that address important advances in the field are highlighted. The underlying premise of this statement is that the addition of CRF for risk classification presents health professionals with unique opportunities to improve patient management and to encourage lifestyle-based strategies designed to reduce cardiovascular risk. These opportunities must be realized to optimize the prevention and treatment of cardiovascular disease and hence meet the American Heart Association's 2020 goals.

1,345 citations