Author
Guillermo Garcia-Garcia
Other affiliations: The George Institute for Global Health, University of Cincinnati, International Society of Nephrology ...read more
Bio: Guillermo Garcia-Garcia is an academic researcher from University of Guadalajara. The author has contributed to research in topics: Kidney disease & Dialysis. The author has an hindex of 30, co-authored 131 publications receiving 5427 citations. Previous affiliations of Guillermo Garcia-Garcia include The George Institute for Global Health & University of Cincinnati.
Papers published on a yearly basis
Papers
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TL;DR: Screening and intervention can prevent chronic kidney disease, and where management strategies have been implemented the incidence of end-stage kidney disease has been reduced, but awareness of the disorder remains low in many communities and among many physicians.
3,207 citations
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University of California, San Diego1, Albany Medical College2, University of São Paulo3, University of Calgary4, University of Guadalajara5, The George Institute for Global Health6, Tufts University7, Chulalongkorn University8, Wake Forest University9, Istanbul University10, University of Leicester11, Yale University12, University of Alberta13, University of Washington14, Mario Negri Institute for Pharmacological Research15
TL;DR: The ability to provide lifesaving treatments for AKI provides a compelling argument to consider therapy forAKI as much of a basic right as it is to give antiretroviral drugs to treat HIV in low-resource regions, especially because care needs only be given for a Published Online March 13, 2015 http://dx.doi.org/10.1016/ S0140-6736(15)60126-X
738 citations
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University of California, San Diego1, University of São Paulo2, Albany Medical College3, University of Leicester4, Yale University5, University of Guadalajara6, Centre Hospitalier Universitaire de Sherbrooke7, The George Institute for Global Health8, Icahn School of Medicine at Mount Sinai9, Wake Forest University10, University of Calgary11, Mario Negri Institute for Pharmacological Research12, University of Milan13
TL;DR: Common aetiological factors across all countries are identified, which might be amenable to a standardised approach for early recognition and treatment of acute kidney injury.
275 citations
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Veterans Health Administration1, University of California, San Francisco2, Duke University3, Johns Hopkins University School of Medicine4, Johns Hopkins University5, University of California, San Diego6, University of Oxford7, Manipal University8, The George Institute for Global Health9, South African Medical Research Council10, University of Cape Town11, Queen Mary University of London12, University of Manitoba13, Cliniques Universitaires Saint-Luc14, Baylor College of Medicine15, Monash University16
TL;DR: KDIGO held a controversies conference and a consensus emerged that CKD screening coupled with risk stratification and treatment should be implemented immediately in high-risk persons and that this should ideally occur in primary or community care settings with tailoring to the local context.
176 citations
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University of Zurich1, University of Washington2, University of Guadalajara3, University of Hassan II Casablanca4, University Medical Center Groningen5, Translational Research Institute6, Princess Alexandra Hospital7, Nanjing University8, Versailles Saint-Quentin-en-Yvelines University9, University of Texas Southwestern Medical Center10, National Institutes of Health11, University College London12, University of Sydney13
TL;DR: A comprehensive, informed approach to prevention that takes into account all of these factors is required to successfully tackle the global CKD epidemic.
142 citations
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01 Mar 2007
TL;DR: An initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI is described.
Abstract: Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Having a uniform standard for diagnosing and classifying AKI would enhance our ability to manage these patients. Future clinical and translational research in AKI will require collaborative networks of investigators drawn from various disciplines, dissemination of information via multidisciplinary joint conferences and publications, and improved translation of knowledge from pre-clinical research. We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI. Members representing key societies in critical care and nephrology along with additional experts in adult and pediatric AKI participated in a two day conference in Amsterdam, The Netherlands, in September 2005 and were assigned to one of three workgroups. Each group's discussions formed the basis for draft recommendations that were later refined and improved during discussion with the larger group. Dissenting opinions were also noted. The final draft recommendations were circulated to all participants and subsequently agreed upon as the consensus recommendations for this report. Participating societies endorsed the recommendations and agreed to help disseminate the results. The term AKI is proposed to represent the entire spectrum of acute renal failure. Diagnostic criteria for AKI are proposed based on acute alterations in serum creatinine or urine output. A staging system for AKI which reflects quantitative changes in serum creatinine and urine output has been developed. We describe the formation of a multidisciplinary collaborative network focused on AKI. We have proposed uniform standards for diagnosing and classifying AKI which will need to be validated in future studies. The Acute Kidney Injury Network offers a mechanism for proceeding with efforts to improve patient outcomes.
5,467 citations
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TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
4,804 citations
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TL;DR: The burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected.
2,370 citations
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TL;DR: The five-year risk of chronic renal failure after transplantation of a nonrenal organ ranges from 7 to 21 percent, depending on the type of organ transplanted, and is associated with an increase by a factor of more than four in the risk of death.
Abstract: Background Transplantation of nonrenal organs is often complicated by chronic renal disease with multifactorial causes. We conducted a population-based cohort analysis to evaluate the incidence of chronic renal failure, risk factors for it, and the associated hazard of death in recipients of nonrenal transplants. Methods Pretransplantation and post-transplantation clinical variables and data from a registry of patients with end-stage renal disease (ESRD) were linked in order to estimate the cumulative incidence of chronic renal failure (defined as a glomerular filtration rate of 29 ml per minute per 1.73 m2 of body-surface area or less or the development of ESRD) and the associated risk of death among 69,321 persons who received nonrenal transplants in the United States between 1990 and 2000. Results During a median follow-up of 36 months, chronic renal failure developed in 11,426 patients (16.5 percent). Of these patients, 3297 (28.9 percent) required maintenance dialysis or renal transplantation. The five-year risk of chronic renal failure varied according to the type of organ transplanted - from 6.9 percent among recipients of heart-lung transplants to 21.3 percent among recipients of intestine transplants. Multivariate analysis indicated that an increased risk of chronic renal failure was associated with increasing age (relative risk per 10-year increment, 1.36; P Conclusions The five-year risk of chronic renal failure after transplantation of a nonrenal organ ranges from 7 to 21 percent, depending on the type of organ transplanted. The occurrence of chronic renal failure among patients with a nonrenal transplant is associated with an increase by a factor of more than four in the risk of death.
1,940 citations
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TL;DR: The large number of people receiving RRT and the substantial number without access to it show the need to both develop low-cost treatments and implement effective population-based prevention strategies.
1,384 citations