Gulnara A. Gaynanova

TL;DR: Different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

TL;DR: Hydroxyethyl bearing gemini surfactants were used to augment phosphatidylcholine based liposomes to achieve higher stability and enhanced cellular uptake and penetration, and liposomal 2-PAM was found to reactivate 27% of brain acetylcholinesterase, which is, to the authors' knowledge, the first example of such high degree of reactivation after intravenous administration ofliposomal drug.

TL;DR: It was demonstrated that the cytotoxicity of TPPB-n in terms of the MTT-test on a human cell line 293T nonmonotonically changes within the homological series, with the highest cytot toxicity exhibited by the dodecyl and tetradecyl homologs.

TL;DR: Using the confocal microscopy method, it was shown that modification of liposomes with a triphenylphosphonium cation results in targeted delivery of encapsulated compounds to mitochondria.

TL;DR: It is demonstrated how the positively charged targeting moieties can be exploited to achieve outstanding mitochondria colocalization with a comparative study of n-tetradecyltriphenylphosphonium bromide and 1-(2-hydroxyethyl)-3- tetradecyl-1H-imidazol-3-ium b romide modified liposomes.