G
Guofa Liu
Researcher at University of Toledo
Publications - 20
Citations - 1844
Guofa Liu is an academic researcher from University of Toledo. The author has contributed to research in topics: Netrin & Axon. The author has an hindex of 16, co-authored 18 publications receiving 1730 citations. Previous affiliations of Guofa Liu include Washington University in St. Louis & Northwestern University.
Papers
More filters
Journal ArticleDOI
Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.
Kit Wong,Xiu Rong Ren,Yang Zhong Huang,Yi Xie,Guofa Liu,Harumi Saito,Hao Tang,Leng Wen,Susann M. Brady-Kalnay,Lin Mei,Jane Y. Wu,Wen Cheng Xiong,Yi Rao +12 more
TL;DR: It is reported here that the intracellular domain of Robo interacts with a novel family of Rho GTPase activating proteins (GAPs) that are expressed in regions responsive to Slit and demonstrated important roles for GAPs and Cdc42 in neuronal migration.
Journal ArticleDOI
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
Guofa Liu,Hilary E. Beggs,Claudia Jürgensen,Hwan Tae Park,Hao Tang,Jessica A. Gorski,Kevin R. Jones,Louis F. Reichardt,Jane Y. Wu,Yi Rao +9 more
TL;DR: The results show the biochemical and functional links between netrin, a prototypical neuronal guidance cue, and FAK, a central player in intracellular signaling that is crucial for cell migration.
Journal ArticleDOI
Activation of FAK and Src are receptor-proximal events required for netrin signaling
Weiquan Li,Jeeyong Lee,Haris G. Vikis,Seung-Hee Lee,Guofa Liu,Jennifer Aurandt,Tang-Long Shen,Eric R. Fearon,Jun-Lin Guan,Min Han,Yi Rao,Kyonsoo Hong,Kun-Liang Guan +12 more
TL;DR: A model in which DCC functions as a kinase-coupled receptor, and FAK and Src act immediately downstream of DCC in netrin signaling is suggested.
Journal ArticleDOI
DSCAM functions as a netrin receptor in commissural axon pathfinding
Guofa Liu,Weiquan Li,Lei Wang,Amar N. Kar,Kun-Liang Guan,Kun-Liang Guan,Yi Rao,Yi Rao,Jane Y. Wu +8 more
TL;DR: It is shown that DSCAM is expressed on commissural axons and interacts with Netrin-1, a prototypical guidance cue for commissial axons, indicating that D SCAM functions as a receptor of netrin- 1.
Journal ArticleDOI
Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling
TL;DR: Findings indicate that netrin stimulation recruits DOCK180 through DCC, which then activates small GTPases, suggesting an essential role for Dock180 in mediating attractive responses by neurons to netrin-1.