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Guoliang Xu
Researcher at Fudan University
Publications - 130
Citations - 19632
Guoliang Xu is an academic researcher from Fudan University. The author has contributed to research in topics: DNA methylation & DNA demethylation. The author has an hindex of 56, co-authored 114 publications receiving 17463 citations. Previous affiliations of Guoliang Xu include Max Planck Society & Laboratory of Molecular Biology.
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Journal ArticleDOI
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
Yu-Fei He,Bin-Zhong Li,Zheng Li,Peng Liu,Yang Wang,Qingyu Tang,Jianping Ding,Yingying Jia,Zhangcheng Chen,Lin Li,Yan Sun,Xiuxue Li,Qing Dai,Chun-Xiao Song,Kangling Zhang,Chuan He,Guoliang Xu +16 more
TL;DR: It is demonstrated that 5mC and 5hmC in DNA are oxidized to 5-carboxylcytosine (5caC) by Tet dioxygenases in vitro and in cultured cells, suggesting that oxidation of 5m C by Tet proteins followed by TDG-mediated base excision of 5caC constitutes a pathway for active DNA demethylation.
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Dnmt3L and the establishment of maternal genomic imprints.
TL;DR: Bisulfite genomic sequencing of DNA from oocytes and embryos showed that removal of Dnmt3L prevented methylation of sequences that are normally maternally methylated, and the defect was specific to imprinted regions, and global genome methylation levels were not affected.
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Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.
Guoliang Xu,Timothy H. Bestor,Déborah Bourc'his,Chih-Lin Hsieh,Niels Tommerup,Merete Bugge,Maj Hultén,Xiaoyan Qu,James J. Russo,E. Viegas-Péquignot +9 more
TL;DR: It is shown that five unrelated ICF patients have mutations in both alleles of the gene that encodes DNA methyltransferase 3B (refs 5, 6), which is the only genetic disorder known to involve constitutive abnormalities of genomic methylation patterns.
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The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
Tian-Peng Gu,Fan Guo,Hui Yang,Hai-Ping Wu,Hai-Ping Wu,Gui-Fang Xu,Wei Liu,Zhi-Guo Xie,Linyu Shi,Xinyi He,Seung-Gi Jin,Khursheed Iqbal,Yujiang Geno Shi,Zixin Deng,Piroska E. Szabó,Gerd P. Pfeifer,Jinsong Li,Guoliang Xu +17 more
TL;DR: Tet3-mediated DNA hydroxylation is involved in epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprograming during animal cloning.
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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1
TL;DR: DNA-(cytosine-5) methyltransferase (MCMT) methylates newly replicated mammalian DNA, but the factors regulating this activity are unknown, and MCMT is shown to bind proliferating cell nuclear antigen (PCNA), an auxiliary factor for DNA replication and repair.