Guoping Liu

TL;DR: Conditional deletion of Sp8, Sp9 and Six3 reveals a regionally specific transcription pathway that selectively drives the generation of striatal DRD2-expressing medium spiny neurons in mouse striatum.

TL;DR: It is shown that Sp8 and Sp9 coordinately regulate OB interneuron development, and newly born neuroblasts in the V-SVZ-RMS-OB system fail to express Prokr2 and Tshz1 expression, genes with known roles in promoting OB interneeuron differentiation and migration, and that are involved in human Kallmann syndrome.

TL;DR: In this article, a single-cell RNA-Seq with intersectional lineage analyses was used to reveal the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocyte and Olfactory bulb interneurons.

TL;DR: It is demonstrated that Sonic hedgehog signaling is both necessary and sufficient for the generation of GSX2+ IPCs by reducing GLI3R protein levels and the process of the lineage switch of cortical NSCs.

TL;DR: It is shown that transcription factors Sp8 and Sp9 are co‐expressed in the subventricular zone (SVZ) of the dorsal CGE and this provides evidence that Sp8/9 coordinately regulate CGE‐derived cortical interneuron development in part through repressing the expression of Pak3, Robo1, and Slit1.