G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
Papers
More filters
Journal ArticleDOI
DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression
Cristiana Cruceanu,Cristiana Cruceanu,Elena Kutsarova,Elena Kutsarova,Elizabeth Suchi Chen,David R. Checknita,Corina Nagy,Juan Pablo Lopez,Martin Alda,Guy A. Rouleau,Gustavo Turecki,Gustavo Turecki +11 more
TL;DR: These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve the understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype.
Journal ArticleDOI
Linkage to the CCM2 locus and genetic heterogeneity in familial cerebral cavernous malformation.
Nicolas Dupré,Dominique J. Verlaan,Collette K. Hand,Sandra B. Laurent,Gustavo Turecki,W. Jeptha Davenport,Nicola Acciarri,Johannes Dichgans,Akio Ohkuma,Adrian M. Siegel,Guy A. Rouleau +10 more
TL;DR: This study is the first one to replicate linkage at the CCM2 locus and provides a fifth family identified as such, and supports the concept of genetic heterogeneity in CCM, identifying four other families that showed no mutations in theCCM1 gene.
Journal ArticleDOI
Refined localization of the gene for Clouston syndrome (hidrotic ectodermal dysplasia) in a large French family
Jérôme Lamartine,D. Laoudj,C. Blanchet-Bardon,Zoha Kibar,P. Soularue,V. Ridoux,L. Dubertret,Guy A. Rouleau,Gilles Waksman +8 more
TL;DR: To define the critical region for HED, detailed haplotypes were constructed with new pericentromeric polymorphic markers and it was confirmed that the HED locus maps centromeric to D13S1832.1.
Journal ArticleDOI
Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.
Iltaf Ahmed,Kirti Mittal,Taimoor I. Sheikh,Taimoor I. Sheikh,Nasim Vasli,Muhammad Rafiq,Anna Mikhailov,Mehrnaz Ohadi,Huda Mahmood,Guy A. Rouleau,Attya Bhatti,Muhammad Ayub,Myriam Srour,Peter John,John B. Vincent,John B. Vincent +15 more
TL;DR: A large consanguineous Pakistani family with 11 cases of congenital MRMV disorder reported across five generations, with autosomal recessive inheritance likely is described, and it is suggested that DNAL4 plays a role in the cytoplasmic dynein complex for netrin-1-directed retrograde transport, and in commissural neurons of the corpus callosum in particular.
Journal ArticleDOI
Differential effect of lithium on spermidine/spermine N1-acetyltransferase expression in suicidal behaviour.
Alessio Squassina,Mirko Manchia,Mirko Manchia,Caterina Chillotti,Valeria Deiana,Donatella Congiu,Francesco Paribello,Paola Roncada,Alessio Soggiu,Cristian Piras,Andrea Urbani,George S. Robertson,Paul G. W. Keddy,Gustavo Turecki,Guy A. Rouleau,Martin Alda,Maria Del Zompo +16 more
TL;DR: The findings suggest that SAT1 transcription is influenced by lithium and that this effect is altered in BD patients who completed suicide, further supporting a role for polyamines in suicide.