G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Identification of a novel homozygous SPG7 mutation by whole exome sequencing in a Greek family with a complicated form of hereditary spastic paraplegia
Hussein Daoud,Eleni Merkouri Papadima,Bouchra Ouled Amar Bencheikh,Theodora Katsila,Alexandre Dionne-Laporte,Dan Spiegelman,Patrick A. Dion,George P. Patrinos,Sandro Orru,Guy A. Rouleau +9 more
TL;DR: The clinical description and genetic analyses of a Greek family with four individuals affected with a complicated form of hereditary spastic paraplegia and a recessive pattern of inheritance led to the identification of a homozygous 25 bp deletion predicted to lead to a frameshift and premature stop codon in the SPG7 gene, encoding paraplegin.
Journal ArticleDOI
Epigenetic Regulation of Synapsin Genes in Mood Disorders
TL;DR: Evidence is found that enrichment of H3K4me3—an epigenetic mark associated with increased transcription—at the promoters of SYN1 and SYN2, but not SYN3 is correlated with increased expression of these genes in the prefrontal cortex of patients with BD and MDD compared with controls.
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HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders.
Sigrid Le Clerc,Laura Lombardi,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune,Azmeraw T. Amare,Klaus Oliver Schubert,Klaus Oliver Schubert,Liping Hou,Scott R. Clark,Sergi Papiol,Micah Cearns,Urs Heilbronner,Franziska Degenhardt,Fasil Tekola-Ayele,Yi-Hsiang Hsu,Tatyana Shekhtman,Mazda Adli,Nirmala Akula,Kazufumi Akiyama,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Lena Backlund,Abesh Kumar Bhattacharjee,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Joanna M. Biernacka,Armin Birner,Clara Brichant-Petitjean,Pablo Cervantes,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Sven Cichon,Cristiana Cruceanu,Piotr M. Czerski,Nina Dalkner,Alexandre Dayer,Maria Del Zompo,J. Raymond DePaulo,Bruno Etain,Stéphane Jamain,Peter Falkai,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Louise Frisén,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Maria Grigoroiu-Serbanescu,Paul Grof,Ryota Hashimoto,Joanna Hauser,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Po-Hsiu Kuo,Tadafumi Kato,John R. Kelsoe,Sarah Kittel-Schneider,Ewa Ferensztajn-Rochowiak,Barbara König,Ichiro Kusumi,Gonzalo Laje,Mikael Landén,Mikael Landén,Catharina Lavebratt,Catharina Lavebratt,Susan G. Leckband,Alfonso Tortorella,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Michael McCarthy,Susan L. McElroy,Francesc Colom,Vincent Millischer,Vincent Millischer,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,Claire O'Donovan,Norio Ozaki,Urban Ösby,Andrea Pfennig,James B. Potash,Andreas Reif,Eva Z. Reininghaus,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Barbara W. Schweizer,Giovanni Severino,Paul D. Shilling,Katzutaka Shimoda,Christian Simhandl,Claire Slaney,Claudia Pisanu,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Mario Maj,Gustavo Turecki,Eduard Vieta,Julia Veeh,Stephanie H. Witt,Adam Wright,Peter P. Zandi,Philip B. Mitchell,Michael Bauer,Martin Alda,Marcella Rietschel,Francis J. McMahon,Thomas G. Schulze,Jean Louis Spadoni,Wahid Boukouaci,Jean Romain Richard,Philippe Le Corvoisier,Caroline Barrau,Jean-François Zagury,Marion Leboyer,Ryad Tamouza +141 more
TL;DR: In this article, a GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region.
Journal ArticleDOI
Correction: Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1
Juliane Winkelmann,Darina Czamara,Barbara Schormair,Franziska Knauf,Eva C. Schulte,Claudia Trenkwalder,Yves Dauvilliers,Olli Polo,Birgit Högl,Klaus Berger,Andrea Fuhs,Nadine Gross,Karin Stiasny-Kolster,Wolfgang H. Oertel,Cornelius G. Bachmann,Walter Paulus,Lan Xiong,Jacques Montplaisir,Guy A. Rouleau,Ingo Fietze,Jana Vavrova,David Kemlink,Karel Sonka,Sona Nevsimalova,Siong-Chi Lin,Zbigniew K. Wszolek,Carles Vilariño-Güell,Matthew J. Farrer,Viola Gschliesser,Birgit Frauscher,Tina Falkenstetter,Werner Poewe,Richard P. Allen,Christopher J. Earley,William G. Ondo,Wei Dong Le,Derek Spieler,Maria Kaffe,Alexander Zimprich,Johannes Kettunen,Markus Perola,Kaisa Silander,Isabelle Cournu-Rebeix,Marcella Francavilla,Claire Fontenille,Bertrand Fontaine,Pavel Vodicka,Holger Prokisch,Peter Lichtner,Paul E. Peppard,Juliette Faraco,Emmanuel Mignot,Christian Gieger,Thomas Illig,H.-Erich Wichmann,Bertram Müller-Myhsok,Thomas Meitinger +56 more
TL;DR: Siong-Chi Lin and Zbigniew Wszolek are also affiliated with: Mayo Clinic, Jacksonville, Florida, United States of America.
Journal ArticleDOI
Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-induced locomotion in recombinant congenic strains (RCS) of mice.
Adam Torkamanzehi,Patricia Boksa,Mouhssine Ayoubi,Marie-Ève Fortier,N.M.K. Ng Ying Kin,Emile Skamene,Guy A. Rouleau,Ridha Joober +7 more
TL;DR: Using recombinant congenic strains of mice derived from A/J and C57BL/6J to identify potential quantitative trait loci associated with AMPH-TDIST may help to identify suitable candidate genes relevant to human disorders where mesolimbic dopamine dysregulation has been postulated.