G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
Papers
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Journal ArticleDOI
Analysis of the SORT1 gene in familial amyotrophic lateral sclerosis.
Veronique V. Belzil,Catherine André-Guimont,Marie Renée Atallah,Hussein Daoud,Nicolas Dupré,Jean-Pierre Bouchard,William Camu,Patrick A. Dion,Guy A. Rouleau +8 more
TL;DR: SORT1 mutations are not a common cause of familial ALS, and the influence of TARDBP mutations on SORT1 splicing still needs to be clarified.
Journal ArticleDOI
Investigating the association and causal relationship between restless legs syndrome and essential tremor
Calwing Liao,Gabrielle Houle,Qin He,Alexandre D. Laporte,Simon Girard,Patrick A. Dion,Guy A. Rouleau +6 more
Patent
Methods of stratifying, prognosing and diagnosing schizophrenia, mutant nucleic acid molecules and polypeptides
TL;DR: In this article, a method for diagnosing the presence of schizophrenia or predicting the risk of developing schizophrenia in a human subject, comprising detecting the presence or absence of a defect in the SHANK3 gene encoding a SHANK 3 polypeptide, in a nucleic acid sample of the subject, whereby the detection of the defect is indicative that the subject has schizophrenia or is at risk for developing schizophrenia.
Journal ArticleDOI
Machine learning analysis of exome trios to contrast the genomic architecture of autism and schizophrenia
Sameer Sardaar,Bill Qi,Alexandre Dionne-Laporte,Guy A. Rouleau,Guy A. Rouleau,Reihaneh Rabbany,Reihaneh Rabbany,Yannis Trakadis,Yannis Trakadis +8 more
TL;DR: It is found that SCZ and ASD cases could be successfully separated based on genetic information, with 86–88% accuracy on the testing dataset.
Journal ArticleDOI
Posttranslational modifications & lithium's therapeutic effect-Potential biomarkers for clinical responses in psychiatric & neurodegenerative disorders.
TL;DR: In this paper, the authors outline the links between lithium's therapeutic mode of action and posttranslational modifications (PTMs) of one, or many, proteins, and explore the putative mechanism of how it restores PTM homeostasis, and thereby cellular physiology.