G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Channelopathies Are a Frequent Cause of Genetic Ataxias Associated with Cerebellar Atrophy
Laurence Gauquelin,Taila Hartley,Mark A. Tarnopolsky,David A. Dyment,Bernard Brais,Bernard Brais,Michael T. Geraghty,Martine Tétreault,Martine Tétreault,Sohnee Ahmed,Samantha K Rojas,Karine Choquet,Jacek Majewski,Francois P. Bernier,Allan Micheil Innes,Guy A. Rouleau,Oksana Suchowersky,Kym M. Boycott,Grace Yoon +18 more
TL;DR: Genetic ataxias associated with cerebellar atrophy are a heterogeneous group of conditions, rendering the approach to diagnosis challenging, and nonspecific imaging finding observed in a number of neurological disorders is observed.
Journal ArticleDOI
The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population
Wejdan M Alenezi,Larissa Milano,Caitlin T Fierheller,Corinne Serruya,Timothée Revil,Kathleen Klein Oros,Supriya Behl,Suzanna L. Arcand,Porangana Nayar,Dan Spiegelman,Simon Gravel,Anne-Marie Mes-Masson,Diane Provencher,William D. Foulkes,Zaki El Haffaf,Guy A. Rouleau,Luigi Bouchard,Celia M. T. Greenwood,Jean-Yves Masson,Jiannis Ragoussis,Patricia N. Tonin +20 more
TL;DR: The role of inherited variants in RAD51C and RAD51D, hereditary ovarian cancer risk genes, in French Canadians of Quebec, Canada exhibits a unique genetic landscape as shown by the frequency of carriers of specific rare pathogenic variants.
Journal ArticleDOI
Reliability and correlation of mixture cell correction in methylomic and transcriptomic blood data.
Boris Chaumette,Oussama Kebir,Oussama Kebir,Patrick A. Dion,Guy A. Rouleau,Marie-Odile Krebs,Marie-Odile Krebs +6 more
TL;DR: The results suggest that a posteriori correction of a mixture of cells present in blood samples is reliable and could be beneficial when there are difficulties to control the cell types in the second dataset, even when the sample size is limited.
Posted ContentDOI
High genetic loading of schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis
Azmeraw T. Amare,Klaus Oliver Schubert,Liping Hou,Scott R. Clark,Sergi Papiol,Urs Heilbronner,Urs Heilbronner,Franziska Degenhardt,Fasil Tekola-Ayele,Yi-Hsiang Hsu,Yi-Hsiang Hsu,Tatyana Shekhtman,Mazda Adli,Nirmala Akula,Kazufumi Akiyama,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Abesh Kumar Bhattacharjee,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Joanna M. Biernacka,Armin Birner,Clara Brichant-Petitjean,Pablo Cervantes,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Sven Cichon,Cristiana Cruceanu,Piotr M. Czerski,Nina Dalkner,Alexandre Dayer,Maria Del Zompo,J. Raymond DePaulo,Bruno Etain,Peter Falkai,Andreas J. Forstner,Andreas J. Forstner,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Maria Grigoroiu-Serbanescu,Paul Grof,Ryota Hashimoto,Joanna Hauser,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Po-Hsiu Kuo,Tadafumi Kato,John R. Kelsoe,Sarah Kittel-Schneider,Sebastian Kliwicki,Barbara König,Ichiro Kusumi,Gonzalo Laje,Mikael Landén,Mikael Landén,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Alfonso Tortorella,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Susan L. McElroy,Francesc Colom,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,Claire O'Donovan,Norio Ozaki,Urban Ösby,Andrea Pfennig,James B. Potash,Andreas Reif,Eva Z. Reininghaus,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Barbara W. Schweizer,Giovanni Severino,Paul D. Shilling,Katzutaka Shimoda,Christian Simhandl,Claire Slaney,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Mario Maj,Gustavo Turecki,Eduard Vieta,Julia Volkert,Stephanie H. Witt,Adam Wright,Peter P. Zandi,Philip B. Mitchell,Michael Bauer,Martin Alda,Marcella Rietschel,Francis J. McMahon,Thomas G. Schulze,Bernhard T. Baune +122 more
TL;DR: Evidence is provided for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPD, and the potential for translational research aimed at personalized prescribing of lithium is suggested.
Journal ArticleDOI
Hyperekplexia and the α1 Subunit Glycine Receptor Gene (GLRA1)
TL;DR: Although in most of the families who have been described, SD shows autosomal dominant inheritance with almost complete penetrance, evidence for recessive transmission has also been reported and two different missense mutations in the same base pair of exon 6 ofGLRA1 have been found.