G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal Article
Parental origin of chromosome 22 alleles lost in meningioma.
M. Sanson,Olivier Delattre,Jérôme Couturier,Jacques Philippon,J Cophignon,P Derome,Guy A. Rouleau,Gareth J. Thomas +7 more
Journal ArticleDOI
Genetic and Epidemiological Study of Adult Ataxia and Spastic Paraplegia in Eastern Quebec.
Ikhlass Haj Salem,Marie Beaudin,Monica Stumpf,Mehrdad Asghari Estiar,Pierre-Olivier Côté,Francis Brunet,Pierre-Luc Gamache,Guy A. Rouleau,Karim Mourabit-Amari,Ziv Gan-Or,Nicolas Dupré +10 more
TL;DR: The minimum prevalence of hereditary ataxias and spastic paraplegias in Eastern Quebec was estimated at 6.47/100 000 [95% CI; 6.44-6.51] with a 95% confidence interval (CI) as mentioned in this paper.
Posted ContentDOI
A comprehensive analysis of dominant and recessive parkinsonism genes in REM sleep behavior disorder
Kheireddin Mufti,Kheireddin Mufti,Uladzislau Rudakou,Uladzislau Rudakou,Eric Yu,Eric Yu,Jennifer A. Ruskey,Jennifer A. Ruskey,Farnaz Asayesh,Farnaz Asayesh,Sandra B. Laurent,Sandra B. Laurent,Dan Spiegelman,Dan Spiegelman,Isabelle Arnulf,Michele T.M. Hu,Jacques Montplaisir,Jean-François Gagnon,Alex Desautels,Yves Dauvilliers,Gian Luigi Gigli,Mariarosaria Valente,Francesco Janes,Birgit Högl,Ambra Stefani,Evi Holzknecht,Karel Sonka,David Kemlink,Wolfgang H. Oertel,Annette Janzen,Giuseppe Plazzi,Elena Antelmi,Elena Antelmi,Michela Figorilli,Monica Puligheddu,Brit Mollenhauer,Claudia Trenkwalder,Friederike Sixel-Döring,Valérie Cochen De Cock,Christelle Charley Monaca,Anna Heidbreder,Luigi Ferini-Strambi,Femke Dijkstra,Mineke Viaene,Beatriz Abril,Bradley F. Boeve,Ronald B. Postuma,Ronald B. Postuma,Guy A. Rouleau,Guy A. Rouleau,Ziv Gan-Or,Ziv Gan-Or +51 more
TL;DR: The results do not support a major role for variants in PRKN, PARK7, PINK1, VPS13C, ATP13A2, FBXO7, PLA2G6, LRRK2, GCH1 and VPS35 in the risk of iRBD.
Posted ContentDOI
Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects
Lynne Krohn,Lynne Krohn,Karl Heilbron,Cornelis Blauwendraat,Regina H. Reynolds,Regina H. Reynolds,Eric Yu,Eric Yu,Konstantin Senkevich,Konstantin Senkevich,Uladzislau Rudakou,Uladzislau Rudakou,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Emil K. Gustavsson,Emil K. Gustavsson,Kajsa Brolin,Jennifer A. Ruskey,Kathryn Freeman,Farnaz Asayesh,Ruth Chia,Isabelle Arnulf,Michele T.M. Hu,Jacques Montplaisir,Jean-François Gagnon,Alex Desautels,Yves Dauvilliers,Gian Luigi Gigli,Mariarosaria Valente,Francesco Janes,Andrea Bernardini,Birgit Högl,Ambra Stefani,Abubaker Ibrahim,Karel Sonka,David Kemlink,Wolfgang H. Oertel,Annette Janzen,Giuseppe Plazzi,Francesco Biscarini,Elena Antelmi,Michela Figorilli,Monica Puligheddu,Brit Mollenhauer,Claudia Trenkwalder,Friederike Sixel-Döring,Valérie Cochen De Cock,Christelle Charley Monaca,Anna Heidbreder,Luigi Ferini-Strambi,Femke Dijkstra,Mineke Viaene,Beatriz Abril,Bradley F. Boeve,Sonja W. Scholz,Mina Ryten,Mina Ryten,Sara Bandres-Ciga,Alastair J. Noyce,Alastair J. Noyce,Paul Cannon,Lasse Pihlstrøm,Mike A. Nalls,Andrew B. Singleton,Guy A. Rouleau,Guy A. Rouleau,Ronald B. Postuma,Ronald B. Postuma,Ziv Gan-Or,Ziv Gan-Or +69 more
TL;DR: This paper performed the first genome-wide analyses on RBD, including genomewide association study, pathway analysis, heritability, genetic correlation, and mendelian randomization, and reported two novel RBD risk loci and replicate three previously reported, and identified key genetic similarities and differences between RBD and other synucleinopathies.
Journal ArticleDOI
Reversibility and Therapeutic Development for Neurodevelopmental Disorders, Insights from Genetic Animal Models.
TL;DR: A review of recent neurobiological advances from experimental models of NDDs can be found in this article , where the expanding property of cutting-edge technologies, such as gene editing and AAV-mediated gene delivery, are leveraged in animal models for the therapeutic development of NDFs.