G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency
Martin H. Berryer,Fadi F. Hamdan,Laura L. Klitten,Rikke S. Møller,Lionel Carmant,Jeremy Schwartzentruber,Lysanne Patry,Sylvia Dobrzeniecka,Daniel Rochefort,Mathilde Neugnot-Cerioli,Jean-Claude Lacaille,Zhiyv Niu,Christine M. Eng,Yaping Yang,Sylvain Palardy,Céline Belhumeur,Guy A. Rouleau,Niels Tommerup,LaDonna Immken,Miriam H. Beauchamp,Gayle Patel,Jacek Majewski,Mark A. Tarnopolsky,Klaus Scheffzek,Helle Hjalgrim,Helle Hjalgrim,Jacques L. Michaud,Graziella Di Cristo +27 more
TL;DR: This study confirms the involvement of SYNGAP1 in autism while providing novel insight into the epileptic manifestations associated with its disruption, and suggests that the de novo missense mutations, p.R579X, and possibly all the other truncating mutations in SYngAP1 result in a loss of its function.
Journal ArticleDOI
Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin.
Jeanne M. McCaffery,Nancy Frasure-Smith,Marie-Pierre Dubé,Pierre Théroux,Guy A. Rouleau,Qingling Duan,François Lespérance +6 more
TL;DR: It appears that the covariation of depressive symptoms and CAD may be attributable, in part, to a common genetic vulnerability; genes within the inflammation and serotonin pathways may serve as good candidates for the first steps in identifying genetic variation important for depression, CAD or both.
Journal ArticleDOI
FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.
Edor Kabashi,Valérie Bercier,Alexandra Lissouba,Meijiang Liao,Edna Brustein,Guy A. Rouleau,Pierre Drapeau +6 more
TL;DR: TARDBP and FUS act in a pathogenic pathway that is independent of SOD1, suggesting that TARDBP acts upstream of FUS in this pathway.
Journal ArticleDOI
Mutations in the calcium-related gene IL1RAPL1 are associated with autism
Amélie Piton,Jacques L. Michaud,Huashan Peng,Swaroop Aradhya,Julie Gauthier,Laurent Mottron,Nathalie Champagne,Ronald G. Lafrenière,Fadi F. Hamdan,S D team,Ridha Joober,Eric Fombonne,Claude Marineau,Patrick Cossette,Marie-Pierre Dubé,Pejmun Haghighi,Pierre Drapeau,Philip A. Barker,Salvatore Carbonetto,Guy A. Rouleau +19 more
TL;DR: The results indicate that mutations in IL1RAPL1 cause a spectrum of neurological impairments ranging from MR to high functioning autism.
Journal ArticleDOI
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Liping Hou,Sarah E. Bergen,Sarah E. Bergen,Nirmala Akula,Jie Song,Christina M. Hultman,Mikael Landén,Mikael Landén,Mazda Adli,Martin Alda,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Judith A. Badner,Thomas B. Barrett,Michael Bauer,Bernhard T. Baune,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Wade H. Berrettini,Abesh Kumar Bhattacharjee,Joanna M. Biernacka,Armin Birner,Cinnamon S. Bloss,Clara Brichant-Petitjean,Elise T. Bui,William Byerley,Pablo Cervantes,Caterina Chillotti,Sven Cichon,Sven Cichon,Francesc Colom,William Coryell,David Craig,Cristiana Cruceanu,Piotr M. Czerski,Tony Davis,Alexandre Dayer,Franziska Degenhardt,Maria Del Zompo,J. Raymond DePaulo,Howard J. Edenberg,Bruno Etain,Peter Falkai,Tatiana Foroud,Andreas J. Forstner,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Elliot S. Gershon,Fernando S. Goes,Tiffany A. Greenwood,Maria Grigoroiu-Serbanescu,Joanna Hauser,Urs Heilbronner,Urs Heilbronner,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Maria Hipolito,Shashi Hitturlingappa,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,John R. Kelsoe,Sarah Kittel-Schneider,Sebastian Kliwicki,Daniel L. Koller,Barbara König,N. Lackner,Gonzalo Laje,Maren Lang,Catharina Lavebratt,William Lawson,Marion Leboyer,Susan G. Leckband,Chunyu Liu,Anna Maaser,Pamela B. Mahon,Wolfgang Maier,Mario Maj,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Susan L. McElroy,Melvin G. McInnis,Rebecca McKinney,Philip B. Mitchell,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Thomas W. Mühleisen,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,John I. Nurnberger,Evaristus A. Nwulia,Urban Ösby,Andrea Pfennig,James B. Potash,Peter Propping,Andreas Reif,Eva Z. Reininghaus,John P. Rice,Marcella Rietschel,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,William A. Scheftner,Peter R. Schofield,Peter R. Schofield,Nicholas J. Schork,Thomas G. Schulze,Johannes Schumacher,Barbara W. Schweizer,Giovanni Severino,Tatyana Shekhtman,Paul D. Shilling,Christian Simhandl,Claire Slaney,Erin N. Smith,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Fabian Streit,Jana Strohmaier,Szabolcs Szelinger,Sarah K. Tighe,Alfonso Tortorella,Gustavo Turecki,Eduard Vieta,Julia Volkert,Stephanie H. Witt,Adam Wright,Peter P. Zandi,Peng Zhang,Sebastian Zöllner,Francis J. McMahon +148 more
TL;DR: A two-stage meta-analysis of GWAS of bipolar disorder patients and controls revealed genome-wide significant associations at two novel loci, adding to a growing list of common autosomal variants involved in BD and illustrating the power of comparing well-characterized cases to an excess of controls in GWAS.