G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Machado-Joseph disease gene products carrying different carboxyl termini.
Jun Goto,Masahiko Watanabe,Yaeko Ichikawa,Su-Bog Yee,Noriyo Ihara,Kotaro Endo,Shuichi Igarashi,Yoshihisa Takiyama,Claudia Gaspar,Patrícia Maciel,Shoji Tsuji,Guy A. Rouleau,Ichiro Kanazawa +12 more
TL;DR: Three cDNA clones for the Machado-Joseph disease gene (MJD1) were isolated and genetic analysis results suggest that Japanese MJD mutations are associated with allele A, which is similar to the previously published one.
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The genomic structure and expression of MJD, the Machado-Joseph disease gene
Yaeko Ichikawa,Jun Goto,Masahira Hattori,Atsushi Toyoda,Kazuo Ishii,Seon-Yong Jeong,Hideji Hashida,Naoki Masuda,Katsuhisa Ogata,Fumio Kasai,Momoki Hirai,Patrícia Maciel,Guy A. Rouleau,Yoshiyuki Sakaki,Ichiro Kanazawa +14 more
TL;DR: Northern blot analysis showed that MJD mRNA is ubiquitously expressed in human tissues, and in at least four different sizes, which indicates that there are three alternative splicing sites and eight polyadenylation signals in MJD that are used to generate the differently sized transcripts.
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Erratum: The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum (Nature Genetics (2002) 32(384-392))
Heidi Carmen Howard,David B. Mount,Daniel Rochefort,Nellie Byun,Nicolas Dupré,Jianming Lu,X. Fan,Luyan Song,Jean-Baptiste Rivière,Claude Prévost,Jürgen Horst,Alessandro Simonati,B. Lemcke,Richard Welch,Roger England,F. Q. Zhan,Adriana Mercado,W. B. Siesser,Alfred L. George,Michael P. McDonald,Jean-Pierre Bouchard,Jean Mathieu,Eric Delpire,Guy A. Rouleau +23 more
Journal ArticleDOI
Identification of shared risk loci and pathways for bipolar disorder and schizophrenia
Andreas J. Forstner,Julian Hecker,Andrea Hofmann,Anna Maaser,Céline S. Reinbold,Céline S. Reinbold,Thomas W. Mühleisen,Markus Leber,Jana Strohmaier,Franziska Degenhardt,Jens Treutlein,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Johannes Schumacher,Fabian Streit,Sandra Meier,Sandra Meier,Sandra Meier,Stefan Herms,Per Hoffmann,André Lacour,Stephanie H. Witt,Andreas Reif,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Susanne Lucae,Wolfgang Maier,Markus Schwarz,Helmut Vedder,Jutta Kammerer-Ciernioch,Andrea Pfennig,Michael Bauer,Martin Hautzinger,Susanne Moebus,Lorena M. Schenk,Sascha B. Fischer,Sascha B. Fischer,Sugirthan Sivalingam,Piotr M. Czerski,Joanna Hauser,Jolanta Lissowska,Neonila Szeszenia-Dabrowska,Paul Brennan,James McKay,Adam Wright,Adam Wright,Philip B. Mitchell,Philip B. Mitchell,Janice M. Fullerton,Janice M. Fullerton,Peter R. Schofield,Peter R. Schofield,Grant W. Montgomery,Sarah E. Medland,Scott D. Gordon,Nicholas G. Martin,Valery Krasnov,Alexander Chuchalin,Gulja Babadjanova,Galina Pantelejeva,Lilia I. Abramova,Alexander S. Tiganov,Alexey Polonikov,Elza Khusnutdinova,Elza Khusnutdinova,Martin Alda,Martin Alda,Cristiana Cruceanu,Cristiana Cruceanu,Guy A. Rouleau,Gustavo Turecki,Catherine Laprise,Fabio Rivas,Fermín Mayoral,Manolis Kogevinas,Maria Grigoroiu-Serbanescu,Tim Becker,Tim Becker,Thomas G. Schulze,Marcella Rietschel,Sven Cichon,Heide Fier,Markus M. Nöthen +83 more
TL;DR: Investigating whether SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset provided further insights into shared risk loci and disease-associated pathways for BD and SCZ.
Journal ArticleDOI
Restless legs syndrome‐associated MEIS1 risk variant influences iron homeostasis
Hélène Catoire,Patrick A. Dion,Lan Xiong,Mourabit Amari,Rébecca Gaudet,Simon Girard,Anne Noreau,Claudia Gaspar,Gustavo Turecki,Jacques Montplaisir,J. Alex Parker,Guy A. Rouleau +11 more
TL;DR: It is shown that RNA interference treatment of the MEIS1 worm orthologue increases ferritin expression in Caenorhabditis elegans and that the RLS‐associated haplotype leads to increased expression offerritin and DMT1 in RLS brain tissues.