G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Unruptured intracranial aneurysms in the Familial Intracranial Aneurysm and International Study of Unruptured Intracranial Aneurysms cohorts: differences in multiplicity and location
Jason Mackey,Robert D. Brown,Charles J Moomaw,Laura Sauerbeck,Richard W. Hornung,Dheeraj Gandhi,Daniel Woo,Dawn Kleindorfer,Matthew L. Flaherty,Irene Meissner,Craig S. Anderson,E. Sander Connolly,Guy A. Rouleau,David F. Kallmes,James C. Torner,John Huston,Joseph P. Broderick +16 more
TL;DR: Heritable structural vulnerability may account for differences in IA multiplicity and location, and important investigations into the underlying genetic mechanisms of IA formation are ongoing.
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Germline deletion in a neurofibromatosis type 2 kindred inactivates the NF2 gene and a candidate meningioma locus
M. Sanson,Claude Marineau,Chantale Desmaze,Mohini Lutchman,Martin H. Ruttledge,Martin H. Ruttledge,Chantal Baron,Steven A. Narod,Olivier Delattre,Gilbert M. Lenoir,Gilles Thomas,Alain Aurlas,Guy A. Rouleau +12 more
TL;DR: Fluorescence in situ hybridization and pulsed field gel electrophoresis confirm the presence of a 700kb deletion which includes the neurofilament heavy chain subunit gene locus (NEFH), D22S268, NF2 and the putative MEN gene, supporting the hypothesis that NF2 results from the inactivation of a tumor suppressor gene on chromosome 22q.
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A mutation in the HSN2 gene causes sensory neuropathy type II in a Lebanese family.
Jean-Baptiste Rivière,Dominique J. Verlaan,Masoud Shekarabi,Ronald G. Lafrenière,Melanie Benard,Vazken M. Der Kaloustian,Zuhayr Shbaklo,Guy A. Rouleau +7 more
TL;DR: Screening of this gene in an HSAN type II Lebanese family showed a 1bp deletion mutation found in a homozygous state in all affected individuals, which supports the hypothesis that HSN2 is the causative gene for HSANtype II.
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Joubert Syndrome in French Canadians and Identification of Mutations in CEP104
Myriam Srour,Myriam Srour,Fadi F. Hamdan,Dianalee McKnight,Erica E. Davis,Hanna Mandel,Jeremy Schwartzentruber,Brissa Martin,Lysanne Patry,Christina Nassif,Alexandre Dionne-Laporte,Luis H. Ospina,Emmanuelle Lemyre,Christine Massicotte,Rachel Laframboise,Bruno Maranda,Damian Labuda,Jean-Claude Décarie,F. Rypens,Dorith Goldsher,Catherine Fallet-Bianco,Jean-François Soucy,Anne-Marie Laberge,Catalina Maftei,Kym M. Boycott,Bernard Brais,Renee-Myriam Boucher,Guy A. Rouleau,Guy A. Rouleau,Nicholas Katsanis,Jacek Majewski,Orly Elpeleg,Mary K. Kukolich,Stavit A. Shalev,Jacques L. Michaud,Jacques L. Michaud +35 more
TL;DR: The observations suggest that CEP104 acts early during cilia formation by regulating the conversion of the mother centriole into the cilia basal body during ciliogenesis, and concludes that disruption of CEP 104 causes JBTS.
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Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study.
Kenji Yamamoto,Joseph F. Cubells,Joel Gelernter,Chawki Benkelfat,Pierre Lalonde,David E. Bloom,Samarthji Lal,Alain Labelle,Gustavo Turecki,Guy A. Rouleau,Ridha Joober +10 more
TL;DR: The results suggest that the DBH gene is not a causative factor in schizophrenia but that it may be a modulator of psychotic symptoms, severity of the disorder and therapeutic response to neuroleptic drugs.