G
Guy A. Rouleau
Researcher at Montreal Neurological Institute and Hospital
Publications - 935
Citations - 75050
Guy A. Rouleau is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 129, co-authored 884 publications receiving 65892 citations. Previous affiliations of Guy A. Rouleau include Utrecht University & University of Helsinki.
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Journal ArticleDOI
Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness
Isabelle Perrault,Isabelle Perrault,Fadi F. Hamdan,Marlène Rio,Marlène Rio,Jose-Mario Capo-Chichi,Nathalie Boddaert,Jean-Claude Décarie,Bruno Maranda,Rima Nabbout,Michel Sylvain,Anne Lortie,Philippe P. Roux,Elsa Rossignol,Xavier Gérard,Xavier Gérard,Giulia Barcia,Patrick Berquin,Arnold Munnich,Arnold Munnich,Guy A. Rouleau,Josseline Kaplan,Josseline Kaplan,Jean-Michel Rozet,Jean-Michel Rozet,Jacques L. Michaud +25 more
TL;DR: Three girls from two nonconsanguineous families affected by a clinical entity characterized by dysmorphic features, early-onset intractable epilepsy, intellectual disability, and cortical blindness are described.
Journal ArticleDOI
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition
Kristopher T. Kahle,Kristopher T. Kahle,Jean François Schmouth,Jean François Schmouth,Valérie Lavastre,Valérie Lavastre,Alban Latremoliere,Jinwei Zhang,Nick Andrews,Takao Omura,Janet Laganière,Janet Laganière,Daniel Rochefort,Daniel Rochefort,Pascale Hince,Geneviève Castonguay,Rébecca Gaudet,Josiane C.S. Mapplebeck,Susana G. Sotocinal,Jingjing Duan,Catherine Ward,Arjun Khanna,Jeffrey S. Mogil,Patrick A. Dion,Patrick A. Dion,Clifford J. Woolf,Perrine Inquimbert,Guy A. Rouleau,Guy A. Rouleau +28 more
TL;DR: In the nerve injury model of neuropathic pain, WNK1/HSN2 contributed to a maladaptive decrease in the activity of the K+-Cl− cotransporter KCC2 by increasing its inhibitory phosphorylation at Thr906 and Thr1007, resulting in an associated loss of GABA (γ-aminobutyric acid)–mediated inhibition of spinal pain-transmitting nerves.
Journal ArticleDOI
Mutations in the netrin-1 gene cause congenital mirror movements
Aurélie Méneret,Elizabeth A. Franz,Oriane Trouillard,Thomas C. Oliver,Yvrick Zagar,Stephen P. Robertson,Quentin Welniarz,R.J. MacKinlay Gardner,Cecile Gallea,Myriam Srour,Christel Depienne,Christel Depienne,Christine L. Jasoni,Caroline Dubacq,Florence Riant,Jean-Charles Lamy,Marie-Pierre Morel,Raphael Guerois,Jessica Andreani,Coralie Fouquet,Mohamed Doulazmi,Marie Vidailhet,Guy A. Rouleau,Guy A. Rouleau,Alexis Brice,Alain Chédotal,Isabelle Dusart,Emmanuel Roze,David Markie +28 more
TL;DR: It is discovered that the anatomy of the corticospinal tract (CST) is abnormal in patients with NTN1-mutant CMM, and the pathophysiology likely involves its loss of function and subsequent disruption of axon guidance, resulting in abnormal decussation of the CST.
Journal ArticleDOI
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Azmeraw T. Amare,Klaus Oliver Schubert,Klaus Oliver Schubert,Liping Hou,Scott R. Clark,Sergi Papiol,Micah Cearns,Urs Heilbronner,Urs Heilbronner,Franziska Degenhardt,Fasil Tekola-Ayele,Yi-Hsiang Hsu,Tatyana Shekhtman,Mazda Adli,Nirmala Akula,Kazufumi Akiyama,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Lena Backlund,Abesh Kumar Bhattacharjee,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Joanna M. Biernacka,Armin Birner,Clara Brichant-Petitjean,Pablo Cervantes,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Sven Cichon,Cristiana Cruceanu,Piotr M. Czerski,Nina Dalkner,Alexandre Dayer,Maria Del Zompo,J. Raymond DePaulo,Bruno Etain,Stéphane Jamain,Peter Falkai,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Louise Frisén,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Maria Grigoroiu-Serbanescu,Paul Grof,Ryota Hashimoto,Joanna Hauser,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Po-Hsiu Kuo,Tadafumi Kato,John R. Kelsoe,Sarah Kittel-Schneider,Sebastian Kliwicki,Barbara König,Ichiro Kusumi,Gonzalo Laje,Mikael Landén,Mikael Landén,Catharina Lavebratt,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Alfonso Tortorella,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Michael McCarthy,Susan L. McElroy,Francesc Colom,Marina Mitjans,Marina Mitjans,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,Claire O'Donovan,Norio Ozaki,Urban Ösby,Andrea Pfennig,James B. Potash,Andreas Reif,Eva Z. Reininghaus,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Barbara W. Schweizer,Giovanni Severino,Paul D. Shilling,Katzutaka Shimoda,Christian Simhandl,Claire Slaney,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Mario Maj,Gustavo Turecki,Eduard Vieta,Julia Veeh,Stephanie H. Witt,Adam Wright,Peter P. Zandi,Philip B. Mitchell,Michael Bauer,Martin Alda,Martin Alda,Marcella Rietschel,Francis J. McMahon,Thomas G. Schulze,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune +134 more
TL;DR: The findings underscore the genetic contribution to lithium response in BD and support the emerging concept of a lithium-responsive biotype in BD.
Journal ArticleDOI
Spinocerebellar ataxia type 6: evidence for a strong founder effect among German families.
Martin Dichgans,Ludger Schöls,Jürgen Herzog,Giovanni Stevanin,H. Weirich-Schwaiger,Guy A. Rouleau,Katrin Bürk,Thomas Klockgether,Christine Zühlke,Franco Laccone,Olaf Riess,T. Gasser +11 more
TL;DR: A strong geographic cluster of spinocerebellar ataxia type 6 (SCA6) families in the Northrhine–Westfalia area is found, suggesting a founder effect in the German SCA6 population.