G
Guy C. Brown
Researcher at University of Cambridge
Publications - 200
Citations - 28948
Guy C. Brown is an academic researcher from University of Cambridge. The author has contributed to research in topics: Microglia & Nitric oxide. The author has an hindex of 81, co-authored 189 publications receiving 25185 citations. Previous affiliations of Guy C. Brown include University College London.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Journal ArticleDOI
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
D. F. S. Rolfe,Guy C. Brown +1 more
TL;DR: The differences in standard metabolic rate between animals of different body mass and phylogeny appear to be due to proportionate changes in the whole of energy metabolism.
Journal ArticleDOI
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
Guy C. Brown,Chris E. Cooper +1 more
TL;DR: Nitric oxide reversibly inhibited oxygen consumption of brain synaptosomes and was apparently competitive with oxygen, suggesting that NO inhibition of cytochrome oxidase and the competion with oxygen may occur in vivo.
Journal ArticleDOI
Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
TL;DR: The results suggest that, although NO may regulate cell respiration physiologically by its action on complex IV, long-term exposure to NO leads to persistent inhibition of complex I and potentially to cell pathology.
Journal ArticleDOI
Nitric oxide and mitochondrial respiration.
TL;DR: In this article, it was shown that low (nanomolar) concentrations of NO specifically inhibit cytochrome oxidase in competition with oxygen, and this inhibition is fully reversible when NO is removed.