Gwendoline Cheng Lian Ee

Bio: Gwendoline Cheng Lian Ee is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Xanthone & Friedelin. The author has an hindex of 21, co-authored 132 publications receiving 1570 citations. Previous affiliations of Gwendoline Cheng Lian Ee include University of Malaya.

Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines

Abstract: Clinacanthus nutans Lindau leaves (CN) have been used in traditional medicine but the therapeutic potential has not been explored for cancer prevention and treatment. Current study aimed to evaluate the antioxidant and antiproliferative effects of CN, extracted in chloroform, methanol, and water, on cancer cell lines. Antioxidant properties of CN were evaluated using DPPH, galvinoxyl, nitric oxide, and hydrogen peroxide based radical scavenging assays, whereas the tumoricidal effect was tested on HepG2, IMR32, NCL-H23, SNU-1, Hela, LS-174T, K562, Raji, and IMR32 cancer cells using MTT assay. Our data showed that CN in chloroform extract was a good antioxidant against DPPH and galvinoxyl radicals, but less effective in negating nitric oxide and hydrogen peroxide radicals. Chloroform extract exerted the highest antiproliferative effect on K-562 (91.28 ± 0.03%) and Raji cell lines (88.97 ± 1.07%) at 100 μ g/ml and the other five cancer cell lines in a concentration-dependent manner, but not on IMR-32 cells. Fourteen known compounds were identified in chloroform extract, which was analysed by gas chromatography-mass spectra analysis. In conclusion, CN extracts possess antioxidant and antiproliferative properties against cultured cancer cell lines, suggesting an alternate adjunctive regimen for cancer prevention or treatment.

Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum

Abstract: Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.

Characterization of flavonoid derivatives from boesenbergia rotunda (l.)

Abstract: Three flavanones, pinostrobin (1), pinocembrin (2) and alpinetin (3) and two chalcones, cardamonin (4) and boesenbergin A (5) were isolated from the hexane and chloroform extracts of rhizomes of Boesenbergia rotunda (L.). The structures of all compounds were elucidated on the basis of spectroscopic data (IR, MS, and NMR) and 2-D NMR was carried out for the structure elucidation of boesenbergin A as a complementary to the spectroscopic data reported previously. Abstrak Tiga sebatian flavanones iaitu pinostrobin (1), pinocembrin (2), dan alpinetin (3) serta dua sebatian chalcones, cardamonin (4) dan boesenbergin A (5) telah diperolehi daripada pemencilan ekstrak heksana dan kloroform daripada rizom Boesenbergia rotunda (L.). Struktur-struktur bagi semua sebatian kimia dikenalpasti berdasarkan data spektroskopi (IR, MS dan NMR) dan 2-D NMR dijalankan untuk pengenalpastian struktur boesenbergin A sebagai maklumat pelengkap kepada data spekstroskopi yang pernah dilaporkan dalam penyelidikan yang lepas.

The Wealth of India

Abstract: IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)