G
Gwendolyn J. Heidecker
Researcher at Merck & Co.
Publications - 19
Citations - 3082
Gwendolyn J. Heidecker is an academic researcher from Merck & Co.. The author has contributed to research in topics: Virus & Simian immunodeficiency virus. The author has an hindex of 15, co-authored 16 publications receiving 2977 citations. Previous affiliations of Gwendolyn J. Heidecker include United States Military Academy.
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Journal ArticleDOI
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.
John W. Shiver,Tong-Ming Fu,Ling Chen,Danilo R. Casimiro,Mary-Ellen Davies,Robert K. Evans,Zhiqiang Zhang,Adam J. Simon,Wendy L. Trigona,Sheri Dubey,Lingyi Huang,Virginia Harris,Romnie Long,Xiaoping Liang,Larry Handt,William A. Schleif,Lan Zhu,Daniel C. Freed,Natasha Persaud,Liming Guan,Kara Punt,Aimin Tang,Minchun Chen,Keith A. Wilson,Kelly B. Collins,Gwendolyn J. Heidecker,V. Rose Fernandez,Helen C. Perry,Joseph G. Joyce,Karen M. Grimm,James C. Cook,Paul M. Keller,Denise S. Kresock,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,Zheng Xu,Kathryn E. Bohannon,David B. Volkin,David C. Montefiori,Ayako Miura,Georgia R. Krivulka,Michelle A. Lifton,Marcelo J. Kuroda,Jörn E. Schmitz,Norman L. Letvin,Michael J. Caulfield,Andrew J. Bett,Rima Youil,David C. Kaslow,Emilio A. Emini +51 more
TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
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Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
Danilo R. Casimiro,Ling Chen,Tong-Ming Fu,Robert K. Evans,Michael J. Caulfield,Mary-Ellen Davies,Aimin Tang,Minchun Chen,Lingyi Huang,Virginia Harris,Daniel C. Freed,Keith A. Wilson,Sheri Dubey,De-Min Zhu,Denise K. Nawrocki,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,William M. Hurni,Zheng Xu,Jeffrey G. Smith,Su Wang,Xu Liu,Liming Guan,Romnie Long,Wendy L. Trigona,Gwendolyn J. Heidecker,Helen C. Perry,Natasha Persaud,Timothy J. Toner,Qin Su,Xiaoping Liang,Rima Youil,Michael Chastain,Andrew J. Bett,David B. Volkin,Emilio A. Emini,John W. Shiver +38 more
TL;DR: Results are suggestive of an immunization strategy for humans that is centered on use of the adenovirus vector and in which existing adenavirus immunity may be overcome by combined immunization with adjuvanted DNA and adenvirus vector boosting.
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Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag
Danilo R. Casimiro,Fubao Wang,William A. Schleif,Xiaoping Liang,Zhiqiang Zhang,Timothy W. Tobery,Mary-Ellen Davies,Adrian B. McDermott,David H. O’Connor,Arthur Fridman,Ansu Bagchi,Lynda G. Tussey,Andrew J. Bett,Adam C. Finnefrock,Tong-Ming Fu,Aimin Tang,Keith A. Wilson,Minchun Chen,Helen C. Perry,Gwendolyn J. Heidecker,Daniel C. Freed,Anthony Carella,Kara Punt,Kara J. Sykes,Lingyi Huang,Virginia I. Ausensi,Margaret Bachinsky,Usha Sadasivan-Nair,David I. Watkins,Emilio A. Emini,John W. Shiver +30 more
TL;DR: The prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors expressing simian immunodeficiency virus (SIV) Gag was examined in rhesus macaques using an SIVmac239 challenge, and virus control was short-lived.
Journal ArticleDOI
Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge
Gayathri Bommakanti,Michael P. Citron,Robert W. Hepler,Cheryl Callahan,Gwendolyn J. Heidecker,Tariq Ahmad Najar,Xianghan Lu,Joseph G. Joyce,John W. Shiver,Danilo R. Casimiro,Jan ter Meulen,Xiaoping Liang,Raghavan Varadarajan +12 more
TL;DR: Biophysical studies and mutational analysis of the protein indicate that it is folded into the desired neutral pH conformation competent to bind the broadly neutralizing HA2 directed monoclonal 12D1, not the low pH conformed observed in previous studies.
Journal ArticleDOI
Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys
Dan H. Barouch,Abie Craiu,Marcelo J. Kuroda,Jörn E. Schmitz,Xin Xiao Zheng,Sampa Santra,Julie D. Frost,Georgia R. Krivulka,Michelle A. Lifton,Carroll L. Crabbs,Gwendolyn J. Heidecker,Helen C. Perry,Mary-Ellen Davies,Hong Xie,Christine E. Nickerson,Tavis D. Steenbeke,Carol I. Lord,David C. Montefiori,Terry B. Strom,John W. Shiver,Mark G. Lewis,Norman L. Letvin +21 more
TL;DR: It is demonstrated that the administration of IL-2/Ig plasmid can substantially augment vaccine-elicited humoral and cellular immune responses in higher primates.