Author
H. B. Henbest
Bio: H. B. Henbest is an academic researcher. The author has contributed to research in topics: Sterol & Group 2 organometallic chemistry. The author has an hindex of 2, co-authored 2 publications receiving 25 citations.
Topics: Sterol, Group 2 organometallic chemistry
Papers
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13 citations
12 citations
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TL;DR: A review of selective reactions and modifications for the partial and total synthesis of steroids can be found in this paper, with a focus on tricyclic intermediates in total synthesis.
61 citations
TL;DR: Evidence was recently presented that an essential part of the accumulation of cholestanol in patients with cerebrotendinous xanthomatosis is due to acceleration of a novel pathway, involving 7α‐hydroxylated intermediates in bile acid biosynthesis as precursors.
47 citations
TL;DR: In this paper, the tetrahydropyranyl (THP) group was efficiently removed using PdCl 2 (CH 3 CN) 2 as catalyst in CH 3 CN, while other protection groups such as p -toluenesulfonyl (Ts), tert-butyldiphenylsilyl (TBDPS), benzyloxycarbonyl, allyl, benzyl (Bn), and benzoyl (Bz) remained intact under these conditions.
47 citations
TL;DR: In this paper, it was shown that hydroxyl compounds readily add to dihydropyran in presence of a catalytic amount of ceric ammonium nitrate to give high yield of tetrahydropyranyl ethers.
43 citations
TL;DR: Acid-catalysed addition of isobutene to steroidal alcohols gives the t-butyl ethers in high yields, which are acid-labile, but alkali-resistant.
Abstract: Acid-catalysed addition of isobutene to steroidal alcohols gives the t-butyl ethers in high yields. These ethers are acid-labile, but alkali-resistant.
The t-butyl group is readily split off with trifluoroacetic acid.
The usefulness of the method is demonstrated by a simple synthesis of testosterone benzoate from dehydroepiandrosterone.
21 citations