H
H. Christian Eberl
Researcher at GlaxoSmithKline
Publications - 25
Citations - 2616
H. Christian Eberl is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Proteomics & Chromatin. The author has an hindex of 14, co-authored 24 publications receiving 2192 citations. Previous affiliations of H. Christian Eberl include Technische Universität München & Max Planck Society.
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Journal ArticleDOI
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Cornelia G. Spruijt,Felix Gnerlich,Arne H. Smits,Toni Pfaffeneder,Pascal W.T.C. Jansen,Christina Bauer,Martin Münzel,Mirko Wagner,Markus Müller,Fariha Khan,Fariha Khan,H. Christian Eberl,Anneloes Mensinga,Arie B. Brinkman,Konstantin Lephikov,Udo Müller,Jörn Walter,Rolf Boelens,Hugo van Ingen,Heinrich Leonhardt,Thomas Carell,Michiel Vermeulen +21 more
TL;DR: Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation.
Journal ArticleDOI
Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers
Michiel Vermeulen,H. Christian Eberl,Filomena Matarese,Hendrik Marks,Sergei Denissov,Falk Butter,Kenneth K. Lee,Jesper V. Olsen,Jesper V. Olsen,Anthony A. Hyman,Henk Stunnenberg,Matthias Mann +11 more
TL;DR: The authors' data reveal a highly adapted interplay between chromatin marks and their associated protein complexes, and reading specific trimethyl-lysine sites by specialized complexes appears to be a widespread mechanism to mediate gene expression.
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A map of general and specialized chromatin readers in mouse tissues generated by label-free interaction proteomics
H. Christian Eberl,Cornelia G. Spruijt,Christian D. Kelstrup,Michiel Vermeulen,Matthias Mann +4 more
TL;DR: A sensitive, label-free histone peptide pull-down technology with extracts of different mouse tissues that defines the chromatin interaction landscape in mouse tissues and reveals a number of specialized readers in tissues such as testis.
Journal ArticleDOI
Hsp90 is regulated by a switch point in the C-terminal domain
Marco Retzlaff,Michael Stahl,H. Christian Eberl,Stephan Lagleder,Jürgen Beck,Horst Kessler,Johannes Buchner +6 more
TL;DR: It is shown that this residue is a conserved, strong regulator of Hsp90 functions, including ATP hydrolysis and chaperone activity, and S‐nitrosylation of this residue allows the fast and efficient fine regulation of HSp90.
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Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
Henrik Johansson,Henrik Johansson,Yi-Chun Isabella Tsai,Ken G. M. Fantom,Chun-wa Chung,Sandra Kümper,Sandra Kümper,Luigi Martino,Daniel Thomas,H. Christian Eberl,Marcel Muelbaier,David House,Katrin Rittinger +12 more
TL;DR: This work has shown that M1-linked polyubiquitin chains are a key regulatory mechanism to control cellular behavior and alterations in the ubiquitin system are linked to many diseases.