H. D. Hollis Showalter

TL;DR: In NP-type C cells, increasing TRPML1's expression or activity was sufficient to correct the trafficking defects and reduce lysosome storage and cholesterol accumulation, and it is proposed that abnormal accumulation of luminal lipids causes secondary lysOSome storage by blocking TRP ML1- and Ca(2+)-dependent lyssomal trafficking.

TL;DR: In this article, the first small-molecule inhibitors of the menin-MLL fusion protein interaction were presented, which specifically bind menin with nanomolar affinities.

TL;DR: It is suggested that it is quite possible to devise improved rifamycin analogs, and improved activity against rifampin-resistant strains by some analogs promises that further work in this area, especially if the information from co-crystal structures with RNA polymerase is applied, should lead to even better analogs.

TL;DR: The preclinical and clinical results of pharmacological strategies to target the de novo pyrimidine biosynthesis pathway as a target for cancer therapy, and in particular, dihydroorotate dehydrogenase (DHODH), are explored.

TL;DR: It is found that small-molecule Usp9x/Usp24 inhibitors may have therapeutic activity in myeloma and improved the drug-like properties of WP1130, and Usp24 protein overexpression was improved.