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H. Nidecker

Bio: H. Nidecker is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 47 citations.

Papers
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Journal ArticleDOI
TL;DR: In this paper, the Darstellung einiger Monoaminotriazine-(1,3,5) beschrieben, einerseits durch Hydrierung der entsprechenden Dichloraminotrazine, and anotherseit durch Umsetzung des leichter erhaltlichen Phenoxytriazins with Aminen.
Abstract: Es wird die Darstellung einiger Monoaminotriazine-(1,3,5) beschrieben, einerseits durch Hydrierung der entsprechenden Dichloraminotriazine, anderseits durch Umsetzung des leichter erhaltlichen Phenoxytriazins mit Aminen. Daneben werden einige Alkyl-dichlortriazine und deren Umsetzung zu Alkylamino-alkyltriazinen beschrieben. Die Alkylamino-triazine konnen am externen N mittels Natriumamid zu tertiaren Basen alkyliert werden.

47 citations


Cited by
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Journal ArticleDOI
TL;DR: A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs.

130 citations

Journal ArticleDOI
TL;DR: In this article, the path of reaction is determined by the character of substituent R4 in 10, where the starting materials are discussed and the scope and limitations of these reactions and accessibility of starting materials is discussed.
Abstract: Mono- and bis-(2-hydroxyphenyl)-s-triazines 4, 14, 18, 22, 28, 29 can be prepared by (a) reaction of salicylic acid esters 2 with amidines 3; (b) reaction of 4H-1, 3-benzoxazin-4-ones 10 with amidines 3; and (c) Friedel-Crafts-reaction of chloro-s-triazines 26, 27 with resorcinol 24. In case (b) the path of reaction is determined by the character of substituent R4 in 10. Scope and limitations of these reactions and accessibility of starting materials are discussed.

48 citations

Book ChapterDOI
01 Jan 1984

48 citations

Book ChapterDOI
TL;DR: The cationization of the azine–nitrogen promotes nucleophilic substitution at all positions, because the electronegativity of the nitrogen is increased and the localization energy and resistance of the π electron system to interact in the transition state with nucleophiles are increased.
Abstract: Publisher Summary This chapter presents the reactivity pattern of azines with nucleophiles, mainly in the reactions of chloro derivatives with an anionic nucleophile (alkoxide) and with a neutral nucleophile (ammonia or aliphatic amine). The alternative mechanisms of nucleophilic substitution of aromatic compounds—namely, heteroaryne mechanism; SN1 mechanism; ring-opening and recyclization; and synchronous or one-stage bimolecular mechanism—are also described in the chapter. The cationization of the azine–nitrogen promotes nucleophilic substitution at all positions, because the electronegativity of the nitrogen is increased. This change increases the electron deficiency (ground state) and decreases the localization energy and resistance of the π electron system to interact in the transition state with nucleophiles. The reversible interaction of the carbonyl group with an azine lone-pair facilitates substitution adjacent to the heteroatom by the anion of a β-hydroxyethyl ketone. A similar cyclic intermediate is presumably responsible for the cyclization of acetylene dicarboxylic esters with azines.

46 citations

Journal ArticleDOI
TL;DR: The SAR development and optimization process with the emphasis on ligand efficiency and physicochemical properties led to the discovery of compound 44 as a potent, selective and orally active PDE4 inhibitor.

36 citations