https://cmapspublic3.ihmc.us/rid=1J2LQ1265-1DFQC1W-TTL/2MAIN_Effect%20of%20silver%20on%20burn%20wound%20infection%20control%20and%20healing_review%20of%20the%20literature.pdf

Effect of silver on burn wound infection control and healing: review of the literature.

Hydrogel wound dressings for bioactive treatment of acute and chronic wounds

The production and application of hydrogels for wound management: A review

A facile method for electrospinning of Ag nanoparticles/poly (vinyl alcohol)/carboxymethyl-chitosan nanofibers

New generation medical textiles are an important growing field with great expansion in wound management products. Virtually new products are coming but also well known materials with significantly improved properties using advanced technologies and new methods are in the centre of research which are highly technical, technological, functional, and effective oriented. The key qualities of fibres and dressings as wound care products include that they are bacteriostatic, anti-viral, fungistatic, non-toxic, high absorbent, non-allergic, breathable, haemostatic, biocompatible, and manipulatable to incorporate medications, also provide reasonable mechanical properties. Many advantages over traditional materials have products modified or blended with also based on alginate, chitin/chitosan, collagen, branan ferulate, carbon fibres. Textile structures used for modern wound dressings are of large variety: sliver, yarn, woven, non-woven, knitted, crochet, braided, embroidered, composite materials. Wound care also applies to materials like hydrogels, matrix (tissue engineering), films, hydrocolloids, foams. Specialized additives with special functions can be introduced in advanced wound dressings with the aim to absorb odours, provide strong antibacterial properties, smooth pain and relieve irritation. Because of unique properties as high surface area to volume ratio, film thinness, nano scale fibre diameter, porosity, light weight, nanofibres are used in wound care. The aim of this study is to outline and review the latest developments and advance in medical textiles and biopolymers for wound management providing the overview with generalized scope about novelties in products and properties.

Advanced textile materials and biopolymers in wound management.

Bacterial colonisation of wounds may delay wound healing. Modern silver-containing dressings are antimicrobial, yet cellular toxicity is a serious side-effect. We provide data for a newly formulated s

Reduced cellular toxicity of a new silver-containing antimicrobial dressing and clinical performance in non-healing wounds.

Objective: This prospective, multicentre application study was conducted to assess the clinical performance of Hydrosorb comfort hydrogel dressing. Method: Eighty-one patients (average age 67 years) with acute or chronic wounds received three dressing changes. The condition of the wound and patient-reported pain were assessed at the beginning and end of the study period. Results: The mean proportion of the wound surface covered with slough fell from 63% to 34%, and the mean area of new granulation and epithelial tissue increased from 25% to 37% and 13% to 28%, respectively. The average wound size decreased from 4.7 x 2.9cm to 3.7 x 2.3cm; 29.6% of the patients reported no pain at baseline, increasing to 56.3% at the final assessment. Conclusion: Both acute and chronic wounds can be effectively treated with the Hydrosorb comfort hydrogel dressing. Declaration of interest: This study was sponsored by Paul Hartmann Ag, Heidenheim, Germany.

Clinical performance of a hydrogel dressing in chronic wounds: a prospective observational study

Mehr als 600 Patienten (Durchschnittsalter 70 Jahre) mit über− wiegend chronischen Wunden, von denen knapp zwei Drittel in− fiziert waren, wurden in einer multizentrischen und ambulant durchgeführten Anwendungsbeobachtung mit der silberhaltigen Salbenkompresse Atrauman Ag behandelt. Im Verlauf der Wund− behandlung, die im Durchschnitt 23 Tage dauerte, wurde der Wundstatus (Beläge, Exsudation, Wundschmerzen, Granula− tionsgewebe, Epithelgewebe) bei jedem der insgesamt drei Ver− bandwechsel dokumentiert. Waren zu Beginn der Studie 9 % der Wunden vollständig und 24,7% stark von Belägen bedeckt, wa− ren es bei der Abschlussuntersuchung nur noch 2 % bzw. 0,8 %. Gleichzeitig stieg der Anteil der Wunden ohne Beläge von 27 % auf 77 %. Auch die Wundexsudation reduzierte sich unter der Be− handlung mit Atrauman Ag. Parallel zum deutlichen Rückgang der Beläge und Exsudation bildete sich vermehrt Granulations− sowie Epithelgewebe. Die Zahl der Wunden mit mittlerer, starker oder vollständiger Epi− thelisierung stieg von 4,5 % auf 45 %. Weitere Parameter, die sich unter Atrauman Ag verbesserten, waren die Wundschmerzen, die Anzahl infizierter Wunden sowie der Zustand der Wundum− gebung. Fazit: Mit Atrauman Ag steht eine wirksame Wundaufla− ge zur Behandlung von infizierten und infektionsgefährdeten Wunden zur Verfügung, die nicht nur in der Exsudationsphase, sondern auch phasenübergreifend eingesetzt werden kann. Abstract

https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-2005-870541.pdf

Die silberhaltige Salbenkompresse Atrauman Ag bei der Behandlung chronischer Wunden

Introduction Depending on the patient's immune status, contamination of a wound with micro-organisms can lead to local or systemic infection (1). In daily practice, especially infections with methicillin-resistant strains of Staphylococcus aureus (MRSA) present a logistic and therapeutic challenge (2). The clinical performance of the silvercontaining ointment dressing Atrauman Ag (PAUL HARTMANN AG, Heidenheim, Germany) in the treatment of infected and infection-prone wounds was investigated in a large observation study.

The silver-containing ointment dressing Atrauman Ag in the treatment of chronic wounds - an observation study on 624 patients

Objective: To assess the clinical efficacy, tolerance and acceptance of a novel, hydroactive-impregnated dressing (Hydrotul) in the local treatment of acute and chronic wounds. Method: In a prospective observational study 24 centres in France, Belgium, Germany and Austria recruited 74 patients. At each dressing change the investigators evaluated the condition of the wound, perilesional skin and patient-reported pain. Overall, five dressing changes were documented, or until complete healing occurred. The hydroactive properties of the dressing were assessed in laboratory tests by measuring fluid absorption capacity and kinetics. Results: Patients were treated for an average of 17 days. The wound condition improved markedly during the observation period. The wound area covered with fibrinous slough decreased from 29% to 14%, epithelialisation increased from 19% to 54% and 22 wounds were completely healed by the end of the study. The number of patients reporting severe and moderate wound pain decreased from 3...

H. Smola

Papers

Reduced cellular toxicity of a new silver-containing antimicrobial dressing and clinical performance in non-healing wounds.

Clinical performance of a hydrogel dressing in chronic wounds: a prospective observational study

Die silberhaltige Salbenkompresse Atrauman Ag bei der Behandlung chronischer Wunden

The silver-containing ointment dressing Atrauman Ag in the treatment of chronic wounds - an observation study on 624 patients

A prospective observational study of the efficacy of a novel hydroactive impregnated dressing