H
Hagir B. Suliman
Researcher at Duke University
Publications - 96
Citations - 6886
Hagir B. Suliman is an academic researcher from Duke University. The author has contributed to research in topics: Mitochondrial biogenesis & Mitochondrion. The author has an hindex of 43, co-authored 93 publications receiving 6127 citations. Previous affiliations of Hagir B. Suliman include International Livestock Research Institute & University of Khartoum.
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Journal ArticleDOI
Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1
TL;DR: Findings consign HO-1/CO signaling through Nrf2 and Akt to the myocardial transcriptional program for mitochondrial biogenesis, provide a rationale for targeted mitochondrial CO therapy, and connect cardiac mitochondrial volume expansion with the inducible network of xenobiotic and antioxidant cellular defenses.
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Survival in critical illness is associated with early activation of mitochondrial biogenesis.
Jane E. Carré,Jean Christophe Orban,Lorenza Re,Karen Felsmann,Wiebke Iffert,Michael Bauer,Hagir B. Suliman,Claude A. Piantadosi,Terry M. Mayhew,Patrick Breen,Martin Stotz,Mervyn Singer +11 more
TL;DR: Eventual survivors responded early to critical illness with mitochondrial biogenesis and antioxidant defense responses, which may partially counteract mitochondrial protein depletion, helping to maintain functionality and energetic status.
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Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia
TL;DR: It is concluded that oxidative and inflammatory processes in the extracellular lung compartment contribute to hyperoxic-induced lung damage and that overexpression of hEC-SOD mediates a protective response to hyperoxia, at least in part, by attenuating the neutrophil inflammatory response.
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Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis
TL;DR: These novel findings disclose a duality of reactive oxygen species (ROS) effect in the heart's response to LPS in which oxidative mitochondrial damage is opposed by oxidant stimulation of biogenesis.
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Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression *
Claude A. Piantadosi,Crystal M. Withers,Raquel R. Bartz,Nancy Chou MacGarvey,Ping Fu,Timothy E. Sweeney,Karen E. Welty-Wolf,Hagir B. Suliman +7 more
TL;DR: A highly structured transcriptional network that couples mitochondrial biogenesis to counter-inflammation with major implications for immune suppression in sepsis is disclosed.