Hai-Yan Fu

Bio: Hai-Yan Fu is an academic researcher from Guizhou University. The author has an hindex of 2, co-authored 2 publications receiving 46 citations.

Investigation of Host–Guest Compounds of Cucurbit[n=5–8]uril with Some Ortho Aminopyridines and Bispyridine

Abstract: Host–guest complexes of cucurbit[n=5–8]uril and some examples of ortho substituted pyridines or aminopyridines were examined by 1H NMR spectroscopy. Portal binding of two ortho aminopyridine free bases, by cucurbit[5]uril, was observed in 1H NMR spectra. Combined cavity and portal binding in cucurbit[6]uril were observed for both the free base 2-aminomethylpyridine, ampy, the HCl salt, ampy·1HCl, and the salt of 2,2′-bispyridine, bpy·1HCl. Two novel complexes were formed with cucurbit[6]uril. The free base ampyas a dual occupant, formed a 2:1 complex, and bpy·1HCl formed a stable asymmetric 1:1 complex. Only portal binding of 2,6-bisaminomethylpyridine and its salts was observed for cucurbit[6]uril. Fast exchange of the free base and pyridineammonium salts was observed for cucurbit[7-8]uril.

Host-guest complexes of cucubit[8]uril with phenanthrolines and some methyl derivatives

Abstract: The host-guest relationship between cucurbit[8]uril, phenanthrolines and some methyl substituted 1,10-phenanthrolines has been investigated by using 1H NMR spectroscopy and fluorescence spectroscopy. The results showed that phenanthrolines as molecular guests bind in the cavity and portal of cucurbit[8]uril in a ratio of 2:1 (guest to host). The phenanthroline isomers 1,10-,1,7- and 4,7- showed red shifts between 47 and 108 nm and pronounced increases in fluorescent intensity. These same isomers produced inclusion complexes with cucur-bit[8]uril which had moderate to fast exchange rates on the 1H NMR time scale. The methyl substituted 1,10-phenanthrolines studied gave stable inclusion complexes in a ratio of 2:1 which showed slow exchange rates. These guests formed п-п stacked pairs which were cavity bound but also partly protruded from only one portal forming unsymmetrical host-guest complexes. In addition, these п-п stacked pairs formed orientation isomers within the confines of the cucur-bit[8]uril cavity.

The cucurbit[n]uril family

Abstract: In 1981, the macrocyclic methylene-bridged glycoluril hexamer (CB[6]) was dubbed "cucurbituril" by Mock and co-workers because of its resemblance to the most prominent member of the cucurbitaceae family of plants--the pumpkin. In the intervening years, the fundamental binding properties of CB[6]-high affinity, highly selective, and constrictive binding interactions--have been delineated by the pioneering work of the research groups of Mock, Kim, and Buschmann, and has led to their applications in waste-water remediation, as artificial enzymes, and as molecular switches. More recently, the cucurbit[n]uril family has grown to include homologues (CB[5]-CB[10]), derivatives, congeners, and analogues whose sizes span and exceed the range available with the alpha-, beta-, and gamma-cyclodextrins. Their shapes, solubility, and chemical functionality may now be tailored by synthetic chemistry to play a central role in molecular recognition, self-assembly, and nanotechnology. This Review focuses on the synthesis, recognition properties, and applications of these unique macrocycles.

Modulators of Protein-Protein Interactions

Abstract: Lech-Gustav Milroy,† Tom N. Grossmann,‡,§ Sven Hennig,‡ Luc Brunsveld,† and Christian Ottmann*,† †Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Department of Biomedical Engineering, Technische Universiteit Eindhoven, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands ‡Chemical Genomics Centre of the Max Planck Society, Otto-Hahn Straße 15, 44227 Dortmund, Germany Department of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany

Cucurbit[n]uril-based coordination chemistry: from simple coordination complexes to novel poly-dimensional coordination polymers

Abstract: Cucurbit[n]urils are a family of molecular container hosts bearing a rigid hydrophobic cavity and two identical carbonyl fringed portals. They have attracted much attention in supramolecular chemistry because of their superior molecular recognition properties in aqueous media. This review highlights the recent advances and challenges in the field of cucurbit[n]uril-based coordination chemistry. It not only presents progress in the knowledge of such macrocyclic compounds, which range from simple to complicated architectures, but also presents new routes of synthesis and their advantages in hybrid porous solids. The concept of structure “inducer” for their structural design to achieve predictable structures and controlled pores is described. The large pore sizes and hydrophobic cavities of these compounds that lead to unprecedented properties and potential applications are also discussed.

Die Cucurbit[n]uril-Familie

Abstract: Im Jahre 1981 tauften Mock und Mitarbeiter das makrocyclische methylenverbruckte Glycoluril-Hexamer (CB[6]) auf den Namen “Cucurbituril” – da ihre Form einem Kurbis ahnelt, dem bekanntesten Mitglied der Cucurbitaceae-Familie in der Pflanzenwelt. In den folgenden Jahren wurden die grundlegenden Bindungseigenschaften von CB[6] – die hohe Affinitat und Selektivitat sowie der Einschluss von Gasten – in bahnbrechenden Arbeiten der Gruppen von Mock, Kim und Buschmann aufgezeigt; es folgten Anwendungen in der Wasseraufarbeitung, kunstlichen Enzymen und molekularen Schaltern. Erst vor kurzem wuchs die Cucurbit[n]uril-Familie um Homologe (CB[5]–CB[10]), Derivate, Verwandte und Analoga, sodass sie nun die Molekulgrosen von α-, β- und γ-Cyclodextrinen umfasst und ubersteigt. Auch die Formen, Loslichkeiten und chemischen Funktionalitaten konnen inzwischen durch spezielle Synthesen den Erfordernissen angepasst werden. Durch diese Eigenschaften sind die Cucurbiturile pradestiniert fur eine zentrale Rolle in molekularer Erkennung, Selbstorganisation und Nanotechnologie. Dieser Aufsatz stellt Synthesen, Erkennungseigenschaften und Anwendungen dieser einzigartigen Makrocyclen vor.