H
Haifa Shen
Researcher at Houston Methodist Hospital
Publications - 129
Citations - 11527
Haifa Shen is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Drug delivery & Cancer. The author has an hindex of 43, co-authored 129 publications receiving 9074 citations. Previous affiliations of Haifa Shen include University of Texas Health Science Center at Houston & Cornell University.
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Journal ArticleDOI
Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Xi Chen,Dimitrios Iliopoulos,Dimitrios Iliopoulos,Qing Zhang,Qianzi Tang,Qianzi Tang,Matthew B. Greenblatt,Maria Hatziapostolou,Maria Hatziapostolou,Elgene Lim,Wai Leong Tam,Min Ni,Yiwen Chen,Junhua Mai,Haifa Shen,Haifa Shen,Dorothy Hu,Stanley Adoro,Bella Hu,Minkyung Song,Chen Tan,Melissa D. Landis,Mauro Ferrari,Mauro Ferrari,Sandra J. Shin,Myles Brown,Jenny C. Chang,X. Shirley Liu,Laurie H. Glimcher +28 more
TL;DR: It is reported that XBP1 is activated in TNBC and has a pivotal role in the tumorigenicity and progression of this human breast cancer subtype, and targeting this pathway may offer alternative treatment strategies for this aggressive subtype of breast cancer.
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New genes involved in cancer identified by retroviral tagging
Takeshi Suzuki,Haifa Shen,Keiko Akagi,Herbert C. Morse,James D. Malley,Daniel Q. Naiman,Nancy A. Jenkins,Neal G. Copeland +7 more
TL;DR: The power of retroviral tagging for cancer gene discovery in the post-genome era is demonstrated and a largely unrecognized complexity in mouse and presumably human cancer is indicated.
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Safety of Nanoparticles in Medicine.
Joy Wolfram,Motao Zhu,Yong Yang,Jianliang Shen,Jianliang Shen,Emanuela Gentile,Donatella Paolino,Massimo Fresta,Guangjun Nie,Chunying Chen,Haifa Shen,Haifa Shen,Mauro Ferrari,Mauro Ferrari,Yuliang Zhao +14 more
TL;DR: The mechanisms for molecular, cellular, organ, and immune system toxicity, which can be observed with a subset of nanoparticles, are discussed and important considerations for nanoparticle safety assessment are reviewed.
Journal ArticleDOI
Leukaemia disease genes: large-scale cloning and pathway predictions
Jiayin Li,Haifa Shen,Karen L. Himmel,Adam J. Dupuy,David A. Largaespada,Takuro Nakamura,John D. Shaughnessy,Nancy A. Jenkins,Neal G. Copeland +8 more
TL;DR: This paper describes an inverse PCR (IPCR) method for proviral tagging that makes use of automated DNA sequencing and the genetic tools provided by the Mouse Genome Project, which increases the throughput for disease gene identification.