H
Haig H. Kazazian
Researcher at Johns Hopkins University School of Medicine
Publications - 317
Citations - 37555
Haig H. Kazazian is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Gene & Retrotransposon. The author has an hindex of 98, co-authored 315 publications receiving 35197 citations. Previous affiliations of Haig H. Kazazian include University of Pennsylvania & Post Graduate Institute of Medical Education and Research.
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Journal ArticleDOI
Mobile elements: drivers of genome evolution.
TL;DR: Mobile elements within genomes have driven genome evolution in diverse ways and are becoming useful tools for learning more about genome evolution and gene function.
Journal ArticleDOI
Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition
TL;DR: It is proposed that L1 EN cleaves the target site for L1 insertion and primes reverse transcription, and mutations in conserved amino acid residues of L1EN abolish its nicking activity and eliminate L1 retrotransposition.
Journal ArticleDOI
High Frequency Retrotransposition in Cultured Mammalian Cells
John V. Moran,Susan E. Holmes,Thierry Naas,Ralph J. DeBerardinis,Jef D. Boeke,Haig H. Kazazian +5 more
TL;DR: It is shown that two human L1 elements (L1.2 and LRE2) can actively retrotranspose in cultured mammalian cells, suggesting a potential role for L1-based vectors in random insertional mutagenesis.
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Hot L1s account for the bulk of retrotransposition in the human population
Brook Brouha,Joshua Schustak,Richard M. Badge,Richard M. Badge,Sheila Lutz-Prigge,Alexander H. Farley,John V. Moran,Haig H. Kazazian +7 more
TL;DR: The data indicate that most L1 retrotransposition in the human population stems from hot L1s, with the remaining elements playing a lesser role in genome plasticity.
Journal ArticleDOI
Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man.
Haig H. Kazazian,Corinne Wong,Hagop Youssoufian,Hagop Youssoufian,Alan F. Scott,Deborah G. Phillips,Stylianos E. Antonarakis +6 more
TL;DR: The results indicate that certain L1 sequences in man can be dispersed, presumably by an RNA intermediate, and cause disease by insertional mutation.