H
Haimei Chen
Researcher at University of Edinburgh
Publications - 14
Citations - 2895
Haimei Chen is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Ruthenium & Guanine. The author has an hindex of 11, co-authored 13 publications receiving 2752 citations. Previous affiliations of Haimei Chen include Western General Hospital & Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Inhibition of cancer cell growth by ruthenium(II) arene complexes
Morris Robert Edward,Rhona E. Aird,Piedad del Socorro Murdoch,Haimei Chen,Jeffrey Cummings,Nathan D. Hughes,Simon Parsons,Andrew Parkin,Gary Boyd,Duncan I. Jodrell,Peter J. Sadler +10 more
TL;DR: These chelated Ru(II) arene complexes have potential as novel metal-based anticancer agents with a mechanism of action different from that of the Ru(III) complex currently on clinical trial.
Journal ArticleDOI
In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer.
R E Aird,Jeffrey Cummings,A.A. Ritchie,M. Muir,Morris Robert Edward,Haimei Chen,Peter J. Sadler,Duncan I. Jodrell +7 more
TL;DR: High activity coupled to non cross-resistance in cisplatin resistant models merit further development of this novel group of anticancer compounds.
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Organometallic Ruthenium(II) Diamine Anticancer Complexes: Arene-Nucleobase Stacking and Stereospecific Hydrogen-Bonding in Guanine Adducts
TL;DR: The structures of monofunctional adducts of the "piano-stool" complexes of the type [(eta(6)-arene)Ru(II)(en)Cl][PF(6)] are determined and the predominance of the syn orientation both in the solid state and in solution can be attributed to hydrophobic interactions between the arene and purine rings.
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Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms.
TL;DR: Investigation of nucleic acid derivatives by organometallic ruthenium(II) arene anticancer complexes has revealed that N7-binding is promoted by favorable arene-purine hydrophobic interactions in the associative transition state.
Journal ArticleDOI
DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.
TL;DR: The results point to a unique profile of DNA binding for Ru(II) arene compounds, suggesting that a search for new anticancer compounds based on this class of complexes may also lead to an altered profile of biological activity in comparison with that of metal-based antitumor drugs already used in the clinic or currently on clinical trials.