Haiyan Cao

TL;DR: It is demonstrated that increased mitochondrial fission plays a critical role in regulation of HCC cell survival, which provides a strong evidence for this process as drug target in HCC treatment.

TL;DR: Evidence supporting a metastasis-promoting role for MCUR1-dependent mitochondrial Ca2+ uptake in HCC is provided and it is suggested thatMCUR1 may be a potential therapeutic target for HCC treatment.

TL;DR: These findings provide the first direct evidence that upregulated MICU1 preserves cardiac function in diabetic db/db mice, suggesting that increasing the expression or activity of MICU 1 may be a pharmacological approach to ameliorate cardiomyopathy in diabetes.

TL;DR: It is found that targeting Drp1-dependent mitochondrial fission may provide a novel strategy for suppressing tumor growth of HCC and the crosstalk between p53 and NF-κB pathways was proved to be involved in the regulation of mitochondrial fissions-mediated cell proliferation.

TL;DR: It is shown that increased mitochondrial fission significantly promoted the proliferation of hepatocellular carcinoma cells and how these dynamics influence the migration of tumour cells remained largely unknown.