H
Haiying Liu
Researcher at Rensselaer Polytechnic Institute
Publications - 7
Citations - 701
Haiying Liu is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Heparin & Heparinoids. The author has an hindex of 7, co-authored 7 publications receiving 654 citations. Previous affiliations of Haiying Liu include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Lessons learned from the contamination of heparin
TL;DR: The heparin contamination crisis, its resolution, and the lessons learned are reviewed, with the conclusion that safer and better-regulated processes are needed for heparIn production.
Journal ArticleDOI
Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds
Sumit Bhattacharyya,Sumit Bhattacharyya,Haiying Liu,Zhenqing Zhang,Murielle Jam,Pradeep K. Dudeja,Pradeep K. Dudeja,Gurvan Michel,Robert J. Linhardt,Joanne K. Tobacman,Joanne K. Tobacman +10 more
TL;DR: Changes in IL-8 production were attributable to the effects of induction of inflammation on the TLR4-BCL10-mediated innate immune pathway, providing new information about the specificity of carbohydrate-protein interaction between CGN andTLR4 and may help to devise treatments that modify the immune reactivity induced by carbohydrate antigens.
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Quantification of Heparan Sulfate Disaccharides Using Ion-Pairing Reversed-Phase Microflow High-Performance Liquid Chromatography with Electrospray Ionization Trap Mass Spectrometry
TL;DR: The ratio of intensities between each pair of enriched and nonenriched disaccharides showed a linear relationship as a function of concentration, and the amount of eachDisaccharide could be quantified in four heparan sulfate samples analyzed by this method.
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Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE
Zhenqing Zhang,Boyangzi Li,Jiraporn Suwan,Jiraporn Suwan,Fuming Zhang,Zhenyu Wang,Haiying Liu,Barbara Mulloy,Robert J. Linhardt +8 more
TL;DR: Heparin adulterated with heparinoids showed additional peaks in their high-field (1)H-NMR spectra, clearly supporting NMR for monitoring of hepar in API with an LOD of 0.5-10%.
Journal ArticleDOI
Lessons Learned from the Contamination of Heparin
TL;DR: Heparin contamination crisis, its resolution, and the lessons learned as mentioned in this paper were reviewed in this Highlight article, where a semi-synthetic oversulfated chondroitin sulfate (OSCS) was traced to contamination with anaphylactoid-type reactions leading to hypotension and death.