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Håkan Thonberg

Researcher at Karolinska Institutet

Publications -  54
Citations -  3477

Håkan Thonberg is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 20, co-authored 40 publications receiving 2729 citations. Previous affiliations of Håkan Thonberg include Karolinska University Hospital.

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Rebecca Sims, +487 more
- 01 Sep 2017 - 
TL;DR: Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease.
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Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

Joacim Elmén, +10 more
- 01 Jan 2005 - 
TL;DR: It is shown that incorporation of LNA substantially enhances serum half-life of siRNA's, which is a key requirement for therapeutic use and evidence that LNA is compatible with the intracellular siRNA machinery and can be used to reduce undesired, sequence-related off-target effects.
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Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

Jonathan D. Rohrer, +63 more
- 01 Mar 2015 - 
TL;DR: Structural imaging and cognitive changes can be identified 5-10 years before expected onset of symptoms in asymptomatic adults at risk of genetic frontotemporal dementia, which could help to define biomarkers that can stage presymPTomatic disease and track disease progression.
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A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

Quan Du, +4 more
- 01 Jan 2005 - 
TL;DR: This study provides direct evidence that the target recognition of siRNA is far more degenerative than previously considered and is instrumental in the understanding of RNAi specificity and may aid the computational prediction of RNA secondary structure.
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A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats

Julie van der Zee, +88 more
- 01 Feb 2013 - 
TL;DR: In vitro reporter gene expression studies demonstrated significantly decreased transcriptional activity of C9orf72 with increasing number of normal repeat units, indicating that intermediate repeats might act as predisposing alleles and in favor of the loss‐of‐function disease mechanism.