Hamed Tavolinejad

Bio: Hamed Tavolinejad is an academic researcher from Tehran University of Medical Sciences. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 10 publications receiving 10 citations.

The interplay between gut microbiota and autism spectrum disorders: A focus on immunological pathways.

Abstract: Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by impairments in social and cognitive activities, stereotypical and repetitive behaviors and restricted areas of interest. A remarkable proportion of ASD patients represent immune dysregulation as well as gastrointestinal complications. Hence, a novel concept has recently emerged, addressing the possible intercommunication between the brain, the immune system, the gut and its commensals. Here, we provide an overview of how gut microbes and their metabolites are associated with neurobehavioral features of ASD through various immunologic mechanisms. Moreover, we discuss the potential therapeutic options that could modify these features.

Efficacy and safety of same‐day discharge after atrial fibrillation ablation: A systematic review and meta‐analysis

Abstract: Conventionally, patients have been admitted overnight after atrial fibrillation (AF) catheter ablation. Several centers have recently adopted a same‐day discharge (SDD) protocol for patients undergoing AF catheter ablation. We aimed to systematically review the current evidence for the safety and efficacy of SDD after AF catheter ablation. A systematic search was performed in PubMed, Embase, Scopus, Web of Science, and the Cochrane library until August 21, 2021. The risk of bias was assessed with the “Methodological Index for Non‐Randomized Studies” (MINORS). The pooled efficacy rate of SDD protocol (defined as the proportion of patients discharged the same day of ablation among the patients who were planned for SDD) was calculated. Meanwhile, pooled major complication rates and early readmission or emergency department (ED) visit rates were evaluated in successful and planned SDD groups separately. Overall, 12 observational studies consisting of 18,065 catheter ablations were included, among which 7320 (40.52%) were discharged the same‐day after ablation. The pooled efficacy was 90.3% (95% confidence interval [CI] [82.7–96.0]). The major complication rates were 1.1% (95%CI [0.5–1.9]), and 0.7% (95% CI [0.0–3.1]) in planned SDD and successful SDD groups, respectively. In addition, readmission/ED visit rate were 3.0% (95%CI [0.9–6.1]), and 3.1% (95% CI [0.8–6.5]) in the same groups. There were no significant differences between planned SDD and overnight groups with respect to major complication rate (risk ratio = 0.70, 95%CI [0.35–1.42], p‐value = .369). The available data indicates that SDD after AF ablation is safe and efficient. Further prospective and randomized studies are warranted to elucidate the safety of SDD after AF ablation and develop a standardized SDD protocol.

Prevalence and trends of coronary artery disease risk factors and their effect on age of diagnosis in patients with established coronary artery disease: Tehran Heart Center (2005-2015).

Abstract: BACKGROUND Coronary artery disease (CAD) is a universal public health challenge, more prominently so in the low- and middle-income countries. In this study, we aimed to determine prevalence and trends of CAD risk factors in patients with documented CAD and to determine their effects on the age of CAD diagnosis. MATERIALS AND METHODS We conducted a registry-based, serial cross-sectional study using the coronary angiography data bank of the Tehran Heart Center. Adult patients who had obstructive (> 50% stenosis) CAD were included in the study. The prevalence and 11-year trends of conventional CAD risk factors were analyzed by sex and age, and their adjusted effects on the age of CAD diagnosis were calculated. RESULTS From January 2005 to December 2015, data for 90,094 patients were included in this analysis. A total of 61,684 (68.5%) were men and 28,410 (31.5%) were women. Men were younger at diagnosis than women, with a mean age of 60.1 in men and 63.2 in women (p < 0.001), and had fewer risk factors at the time of diagnosis. Mean age at diagnosis had an overall increasing trend during the study period. Increasing trend was seen in body-mass index, hypertension prevalence, diabetes mellitus. All lipid profile components (total cholesterol, low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol) decreased over time. Of particular interest, opium consumption was associated with 2.2 year earlier age of CAD diagnosis. CONCLUSION The major results of this study (lower age of CAD diagnosis in men, lower age of diagnosis associated with most risk factors, and lower prevalence of serum lipids over time) were expected. A prominent finding of this study is confirming opium use was associated with a much younger age of CAD onset, even after adjusting for all other risk factors. In addition to recommendations for control of the traditional risk factors, spreading information about the potential adverse effect of opium use, which has only recently been associated with higher risk of CAD, may be necessary.

Social Media Application as a New Paradigm for Business Communication: The Role of COVID-19 Knowledge, Social Distancing, and Preventive Attitudes

Abstract: Business firms and the public have encountered massive consequences of the COVID-19 pandemic. This pandemic has become the most significant challenge and influenced all communities. This research study focuses on exploring the relationship between COVID-19 knowledge, social distancing, individuals' attitudes toward social media use, and practices of using social media amid the COVID-19 crisis. This study examines how attitudes toward social media use mediate the linkage between COVID-19 knowledge, social distancing, and practices for social media use. This survey uses a non-probability convenience sampling approach to collect samples and recruit willing respondents with their consent for data collection. This study recorded the feedback from 348 participants who encountered the indirect/direct effects of nationwide lockdowns, restrictions on social gatherings, and COVID-19 infection. The findings validate the proposed hypotheses for their direct effects and indicate significant β-values, t-statistics, and the p-values at p <0.001. The results validate a relationship between the COVID-19 knowledge of and social distancing practices. Similarly, the results approved a positive link between social distancing and attitudes toward social media use amid COVID-19. The findings validate the relation between social distancing and attitudes toward social media use during COVID-19 challenges (β-value = 0.22 and t-statistics = 3.078). The results show the linkage between attitudes toward social media use and practices of using social media (β-value = 0.41, and t-statistics = 7.175). Individuals' attitude toward social media use during COVID-19 mediates the connection between COVID-19 knowledge and COVID-19 practices of using social media use. The results validate the first mediation at β-value = 0.21 and t-statistic = 5.327. Similarly, the findings approve that attitudes toward social media use in the pandemic have positively mediated the relation between distancing and practices for social media use amid the crisis of COVID-19 (β-value = 0.09 and t-statistic = 2.633). The findings indicate how people have been indulged in social media to pave their business communication needs. The results provide valuable insights for the global business community. This study provides a systematic and holistic research model that helps in exploring the consequences of COVID-19. The generalizability of the findings provides valuable directions for future research related to the current pandemic.

Assessing Factors Influencing Technology Adoption for Online Purchasing Amid COVID-19 in Qatar: Moderating Role of Word of Mouth

Abstract: The COVID-19 pandemic developed new challenges for global consumers. In response to this disaster, digital technology users have faced the necessity to adopt and use specific technology apps for online shopping. This article examines how contingencies disrupt existing theoretical models and their implications for the post-COVID-19 era for online purchases. Customers prefer apps to use on the websites for search and purchase amid the COVID-19 crisis. The websites offer competitive advantages to apps for branding and CRM prospects. This motive keeps customers happy and satisfied with the website offers. This study focuses on consumer electronics and observes the comparative influence of fundamental elements (i.e., hedonic motivation, habits, perceived risk, technological trust, and technological awareness) on purchasing customer satisfaction. The study further examines the impact of customer satisfaction with online purchases with website continuance intention (WCI). Notably, this study explores the moderating effect of word-of-mouth (WOM) on the relationship between customer satisfaction with online purchases and website continuance intention. This study designed a web-based survey and recruited frequent visitors including international and citizens of Qatar for data collection. The study employed a purposive sampling technique and used three standardized psychological tools to obtain the data set needed to measure customer satisfaction with online purchases. The survey used a web link, distributed 600 questionnaires via email and social media, and received only 468 responses. After screening, only 455 were valid responses. The study showed a response rate of 75.83%. The study results showed that hedonic motivation, habits, perceived risk, and technological awareness were positively related to customer satisfaction with online purchasing. Besides, customer satisfaction with subsequent online purchases is also positively associated with website continuance intention (WCI). The results revealed that this relationship remained stronger when word-of-mouth (WOM) was higher. Hence, this shows that online shopping is seen as a vital and interesting activity in the Qatari context. The findings provide useful insights for future studies to explore the effects of COVID-19 on online purchase intentions.

Survival in Pandemic Times: Managing Energy Efficiency, Food Diversity, and Sustainable Practices of Nutrient Intake Amid COVID-19 Crisis

Abstract: The COVID-19 pandemic led to an economic crisis and health emergency, threatening energy efficiency consumption, sustainable food diversity, and households’ nutrition security. The literature documented that environmental threats can divert attention from renewable energy and food security challenges that affect humans’ environmental behaviors. The COVID-19 crisis has consistently influenced environmental behaviors, as it primarily decreased income and disrupted food systems worldwide. This study investigated the COVID-19 consequences on household income, sustainable food diversity, sustainable energy consumption, and nutritional security challenges. The study used a self-structured online survey due to non-pharmaceutical restrictions and collected data from 728 households. The investigators applied t-test and logit regression to analyze the data for drawing results. Descriptive statistics show that COVID-19 has adversely affected the income of more than two-thirds (67%) of households. The pandemic has influenced households’ food consumption, energy, and dietary patterns to safeguard their income. The t-test analysis indicated that households’ food diversity and energy consumption significantly declined during the pandemic, and households consumed low-diversified food to meet their dietary needs more than twofold compared to pre-pandemic levels. The results showed that all nutrient consumption remained considerably lower in the COVID-19. Cereals are the primary source of daily dietary needs, accounting for over two-thirds of total energy and half of the nutrient consumption amid COVID-19. The share of vegetables and fruits in household energy consumption dropped by 40 and 30%. Results exhibited that increasing monthly income was inversely associated with worsening food diversity and intake with energy efficiency. Compared with farmers and salaried employment, wage earners were 0.15 and 0.28 times more likely to experience a decline in consuming food diversity. Medium and large households were 1.95 times and 2.64 times more likely than small, to experience decreased food diversity consumption. Launching a nutrition-sensitive program will help minimize the COVID-19 impacts on energy consumption, food diversity, and nutritional security for low-income individuals. This survey relied on the recall ability of the households for the consumed quantities of food commodities, which may lack accuracy. Longitudinal studies employing probability sampling with larger samples can verify this study’s insightful results.

The microbiota-microglia axis in central nervous system disorders

Abstract: The innate immune system in the central nervous system (CNS) is mainly represented by specialized tissue-resident macrophages, called microglia. In the past years, various species-, host- and tissue-specific as well as environmental factors were recognized that essentially affect microglial properties and functions in the healthy and diseased brain. Host microbiota are mostly residing in the gut and contribute to microglial activation states, for example, via short-chain fatty acids (SCFAs) or aryl hydrocarbon receptor (AhR) ligands. Thereby, the gut microorganisms are deemed to influence numerous CNS diseases mediated by microglia. In this review, we summarize recent findings of the interaction between the host microbiota and the CNS in health and disease, where we specifically highlight the resident gut microbiota as a crucial environmental factor for microglial function as what we coin "the microbiota-microglia axis."

From Cultural Tourism to Social Entrepreneurship: Role of Social Value Creation for Environmental Sustainability

Abstract: Cross-cultural exchanges among the locals and the tourists have been beneficial in terms of social value creation and sustainability. The present study has examined the role of cultural tourism and social entrepreneurship on social value creation and environmental sustainability. The study has drawn a sample through a non-probabilistic convenience sampling method for desired data collection, as investigators approached tourists visiting the tourism destinations. The study reports data received with the help of tourists visiting cultural heritage in the Gilgit-Baltistan region of Pakistan. The study has employed the PLS_SEM approach for analysis purposes to draw the results. The findings showed a significant relationship between cultural tourism, environmental sustainability, and social value creation that significantly predicts environmental sustainability. The results revealed a significant positive association between social entrepreneurship, social value creation, and environmental sustainability. Besides, results showed that social value creation mediates the relationship between cultural tourism and environmental sustainability and social entrepreneurship and environmental sustainability. The study’s findings climax the importance of cross-cultural interactions that enriches the cultural understanding and gives new perspectives to the existing cultural traditions. Pursuing environmental sustainability through social value creation requires an excellent combination of the administrative and political collaborative strategy that integrates cultural tourism and social entrepreneurship in tourist destination development and aims to attain improved tourist attractions. Besides, this research identifies a significant effect of cultural tourism on environmental sustainability. However, the relationship between tourism and environmental sustainability is bidirectional. It might provide direction for further study. The findings deliver valuable insight into global cultural tourism and social entrepreneurship activities that provide tourism destinations for community development. This investigation produces a systematic and holistic research framework to help explore the influence of cultural tourism and social value creation on the environmental sustainability at tourism destinations. The generalizability of the findings supplies helpful directions for future research on environmental sustainability related to social entrepreneurship and cultural tourism that leads to social value creation.