Author
Hamit Alyar
Bio: Hamit Alyar is an academic researcher from Çankırı Karatekin University. The author has contributed to research in topics: Carbonic anhydrase II & Density functional theory. The author has an hindex of 10, co-authored 13 publications receiving 213 citations.
Papers
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TL;DR: In this paper, new Schiff bases were synthesized (Z)-4-((4-(diethylamino)benzylidene)amino)-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide (L1) and (Z]-4-(4-(dimethylamino), amino amino) amino)-n-(5-methylisoxosol-3-yl), N-(5 -methylisocazol)-3 -yl)benedienesulfoneamide (
45 citations
TL;DR: Schiff bases and 1,8-bis(thiophene-2-carboxaldimine)-p-menthane (L1 and L2) have been synthesized and characterized by elemental analysis, 1H 13C NMR, UV-vis, FT-IR and LC-MS methods as discussed by the authors.
41 citations
01 Jan 2013
TL;DR: In this paper, the nonlinear optical properties of 27 selected donor-acceptor isomeric derivatives of naphthalene, quinoline and quinazoline, including electron donor molecules such as phenyl, aminophenyl, and N, N-dimethylaminyl, were discussed and compared with literature values.
Abstract: The nonlinear optical properties of 27 selected donor-acceptor isomeric derivatives of naphthalene, quinoline, quinazoline and triazanaphthalene, including electron donor molecules such as phenyl, aminophenyl, and N, N-dimethylaminophenyl, were discussed and compared with literature values. The theoretical calculations were performed with three different hybrid density functional theories (DFT) i.e. BPV86, B3LYP and B3PW91, and 6-311++G(2d,p) basis set was used. The results show that these molecular systems have large first static hyperpolarizabilities. In addition, the NLO response of these molecular systems decreases dramatically when the N, N-dimethylaminophenyl is replaced by aminophenyl or phenyl. This study is extended to the determination of AM1 semi empirical polarizability together with FH6GcgSA(fkWBb(d(USAbaASd(lST(A(fkge(CYB(AAWdveeUZWBWSCVBaAWUgASdhaAgBWUSAUgASf(aCe from optimized geometries using HyperChem v7. Semi empirical AM1 and QSAR-quality empirical polarizability calculations showed poor quantitative agreement with the DFT results, but give excellent statistical correlation coefficients with the DFT values. This implies that the results of such lower calculations can suitably scale for predictive purpose.
33 citations
TL;DR: Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO-LUMO energy gap play key roles in the antimicrobial activity.
32 citations
TL;DR: In this paper, the synthesis of new Schiff bases (E) N-(3,4-dimethylisoxazol-5-yl)-4-((2-hydroxy-4-methoxybenzylidene)amino)benzenesulfonamide (L2), N-(5-methylisoxozol-3-yl)benzene sulfonamide(L3), and substituted salicylaldehydes and their Pd (II), Cu (II) complexes were synthesized for the first time.
30 citations
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12 Nov 2014
TL;DR: The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions.
Abstract: The continuous search for new molecules with therapeutic abilities has led to the synthesis and characterization of a large number of metal complexes, proven to exhibit potential as pharmacological agents through their antibacterial, antiviral, antifungal and antineoplastic properties. As serum albumins play a key role in drug pharmacokinetics and pharmacodynamics, the study of coordination compounds affinity towards this class of proteins, as well as understanding the mechanism through which they interact is crucial. The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions.
125 citations
TL;DR: The theoretical calculations of Benzyl-3-N-(2,4,5-trimethoxyphenylmethylene)hydrazinecarbodithioate and in silico studies predicted that the compound has good drug like character.
124 citations
TL;DR: This work describes the bioinorganic strategies with multiple mechanisms of action based on i) small metal complexes, ii) metal modified macromolecules, iii) metal and metal oxides nanoparticles, iv) light-activated bioin organic platforms, to overcome the pathogen's resistance.
109 citations
TL;DR: The coordination of metal ion has a pronounced effect on the microbial activities of the bis Schiff base ligand, and all the metal complexes have shown higher antimicrobial effect than the free bis Schiffbase ligand.
69 citations
TL;DR: Two new hydrazone ligands and some metal complexes showed antimicrobial activity and coordination sites with the copper(II) ion are phenolic oxygen, azomethine nitrogen and triazinic nitrogen (H2L(1) ligand) or isatinic oxygen (H 2L(2)ligand).
68 citations