H
Han-Shen Tae
Researcher at Illawarra Health & Medical Research Institute
Publications - 50
Citations - 649
Han-Shen Tae is an academic researcher from Illawarra Health & Medical Research Institute. The author has contributed to research in topics: Nicotinic agonist & Nicotinic acetylcholine receptor. The author has an hindex of 13, co-authored 40 publications receiving 473 citations. Previous affiliations of Han-Shen Tae include Australian National University & RMIT University.
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Journal ArticleDOI
A dihydropyridine receptor α1s loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor
Yanfang Cui,Han-Shen Tae,Nicole C. Norris,Yamuna Karunasekara,Pierre Pouliquin,Philip G. Board,Angela F. Dulhunty,Marco G. Casarotto +7 more
TL;DR: Investigating the structure of the DHPR II-III loop using a suite of NMR techniques revealed that it is an intrinsically unstructured protein (IUP) and as such belongs to a burgeoning structural class of functionally important proteins.
Journal ArticleDOI
Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.
Bodil B. Carstens,Géza Berecki,James T. Daniel,Han Siean Lee,Kathryn A. V. Jackson,Han-Shen Tae,Han-Shen Tae,Mahsa Sadeghi,Mahsa Sadeghi,Joel Castro,Tracy O'Donnell,Annemie Deiteren,Stuart M. Brierley,David J. Craik,David J. Adams,David J. Adams,Richard J. Clark +16 more
TL;DR: Structural determination by NMR spectroscopy helped to identify a simplified biologically active eight residue peptide motif containing a single disulfide bond that is an excellent lead molecule for developing a new generation of analgesic peptide drugs.
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α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors
Jingjing Wan,Johnny X. Huang,Irina Vetter,Mehdi Mobli,Joshua Lawson,Han-Shen Tae,Nikita Abraham,Blessy Paul,Mark E. Cooper,David J. Adams,Richard J. Lewis,Paul F. Alewood +11 more
TL;DR: Findings indicate that multimeric ligands can significantly enhance conotoxin potency and selectivity at homomeric nicotinic ion channels.
Journal ArticleDOI
3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM.
Alex Perálvarez-Marín,Han-Shen Tae,Philip G. Board,Marco G. Casarotto,Angela F. Dulhunty,Montserrat Samsó,Montserrat Samsó +6 more
TL;DR: This work reports here the first 3D localization of a SPRY2 domain in any known RyR isoform using three different antibodies against the SPRY 2 domain.
Journal ArticleDOI
Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor
TL;DR: Evidence is discussed that the SPRY2 domain in RyR1 supports interactions with binding partners that contain a structural surface of aligned basic residues that maintain the structural integrity of a protein.