Han W. Tun

TL;DR: Increased SCD1 expression supports ccRCC viability and therefore it is proposed as a novel molecular target for therapy either independently or in combination with an mTOR inhibitor for patients whose disease cannot be remedied with surgical intervention, such as in cases of advanced or metastatic disease.

TL;DR: The results suggest that bio-inspired nanoparticle surface design may enable evasion of specific components of the immune system and provide a rational approach for developing immune tolerant nanomedicines.

TL;DR: A model in which normal renal epithelial cells undergo dedifferentiation, EMT, and adipogenic transdifferentiation is proposed, resulting in ccRCC, characterized by a lack of epithelial differentiation, mesenchymal/adipogenic trans Differentiation, and pluripotent meschymal stem cell-like differentiation capacity in vitro.

TL;DR: The gene expression signature discovered in this study may represent a true "CNS signature" because it contrasted PCNSL with wide-spectrum non-CNS DLBCL on a genomic scale and performed an in-depth bioinformatic analysis.

TL;DR: It is shown that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccRCC primary tumors and metastases, and that it contributes to tumor cell viability and promotes cell migration through its interaction with the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4.