Han Wei Hou

TL;DR: The spiral biochip identifies and addresses key challenges of the next generation CTCs isolation assay including antibody independent isolation, high sensitivity and throughput (3 mL/hr); and single-step retrieval of viable C TCs.

TL;DR: This review describes the current state-of-the-art in microfluidics-based cell separation techniques, and common separation metrics, including separation markers, resolution, efficiency, and throughput, of these techniques are discussed.

TL;DR: A high-throughput size-based separation method for processing diluted blood using inertial microfluidics is introduced, demonstrating the isolation of cancer cells spiked in blood by exploiting the difference in size between CTCs and hematologic cells.

TL;DR: It is demonstrated using microfluidics that stiffer malaria-infected RBCs (iRBCs) behave similar to leukocytes and undergo margination towards the sidewalls, which provides better understanding of the hemodynamic effects of iR BCs in microcirculation and its contribution to pathophysiological outcome relating to cytoadherence to endothelium.

TL;DR: It is demonstrated that a simple microfluidic device can be used to distinguish the difference in stiffness between benign and cancerous breast cells.