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Hanan Ml El-Gamal

Bio: Hanan Ml El-Gamal is an academic researcher from Pharos University in Alexandria. The author has contributed to research in topics: Dried apricot. The author has co-authored 1 publications.
Topics: Dried apricot

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TL;DR: These remarkable hazardous effects of SO2 on male albino mice could be used as a potential guide for the prediction of its human health impact, and consumers could be advised to prevent excessive consumption of the drink (Qamar Al-Deen) prepared from dried apricot leather.
Abstract: Sulphur dioxide (SO2) is used as a preservative in food to prevent its discolouration, and to inhibit the growth of bacteria. Little data is available concerning its in vivo hazardous impact.The present study is therefore designed to examine the cyto-genotoxic potential and the testicular histological alterations in adult mice, induced by SO2 present in the dried apricot leather used to prepare the oriental drink Qamar Al-Deen. Two different forms of drinks were tested; cold and boiled drinks. Animals were placed into 4 groups. The first group received distilled water as a negative control.The second and third groups received orally the drink for 28 days in the form of a cold and a boiled drink, respectively. Animals of the fourth group received cyclophosphamide, they were used as a positive control for cyto-genotoxic tests. The chromosomal aberrations, as well as sperm abnormalities, were significantly elevated in animals that received the two different drink preparations. The mitotic index significantly decreased in comparison with negative and positive controls. Furthermore, histological examination showed different degrees of alterations in the testis. Our results suggest that the presence of SO2 inside the apricot leather might be responsible for these changes. Thus, these remarkable hazardous effects of SO2 on male albino mice could be used as a potential guide for the prediction of its human health impact. Furthermore, consumers could be advised to prevent excessive consumption of the drink (Qamar Al-Deen) prepared from dried apricot leather.

3 citations


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TL;DR: In this article , a follow-up opinion assesses data provided by interested business operators (IBOs) and additional evidence identified in the publicly available literature, concluding that the available toxicity database was inadequate to derive an ADI and withdrew the current temporary group acceptable daily intake (ADI).
Abstract: Abstract Sulfur dioxide–sulfites (E 220–228) were re‐evaluated in 2016, resulting in the setting of a temporary ADI of 0.7 mg SO2 equivalents/kg bw per day. Following a European Commission call for data, the present follow‐up opinion assesses data provided by interested business operators (IBOs) and additional evidence identified in the publicly available literature. No new biological or toxicological data addressing the data gaps described in the re‐evaluation were submitted by IBOs. Taking into account data identified from the literature search, the Panel concluded that there was no substantial reduction in the uncertainties previously identified in the re‐evaluation. Therefore, the Panel considered that the available toxicity database was inadequate to derive an ADI and withdrew the current temporary group acceptable daily intake (ADI). A margin of exposure (MOE) approach was considered appropriate to assess the risk for these food additives. A lower confidence limit of the benchmark dose of 38 mg SO2 equivalents/kg bw per day, which is lower than the previous reference point of 70 mg SO2 equivalents/kg bw per day, was estimated based on prolonged visual evoked potential latency. An assessment factor of 80 was applied for the assessment of the MoE. At the estimated dietary exposures, when using a refined exposure scenario (Data set D), MOEs at the maximum of 95th percentile ranges were below 80 for all population groups except for adolescents. The dietary exposures estimated using the maximum permitted levels would result in MOEs below 80 in all population groups at the maximum of the ranges of the mean, and for most of the population groups at both minimum and maximum of the ranges at the 95th percentile. The Panel concluded that this raises a safety concern for both dietary exposure scenarios. The Panel also performed a risk assessment for toxic elements present in sulfur dioxide–sulfites (E 220–228), based on data submitted by IBOs, and concluded that the maximum limits in the EU specifications for arsenic, lead and mercury should be lowered and a maximum limit for cadmium should be introduced.

1 citations

Journal ArticleDOI
TL;DR: In this paper , a simple colorimetric array has been used to detect sulfur dioxide residues in foods using principal component analysis (PCA), hierarchical clustering analysis (HCA), and linear discriminant analysis (LDA).
Abstract: Discrimination and detection of sulfur dioxide residues in foods using a simple colorimetric array have been achieved. The difference maps before and after the reaction showed that the specific color fingerprint was related to the amount of sulfur dioxide. The results of principal component analysis (PCA), hierarchical clustering analysis (HCA) and linear discriminant analysis (LDA) demonstrated that the as-fabricated colorimetric sensor array have good performance for the discrimination of sulfur dioxide and other interferents, as well as different concentrations of sulfur dioxide. Moreover, the array has been successfully applied to determine the concentration of sulfur dioxide residues in real samples and revealed good accuracy, precision and repeatability.