H
Hanane Laklai
Researcher at University of California, San Francisco
Publications - 11
Citations - 3692
Hanane Laklai is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Pancreatic cancer & Stromal cell. The author has an hindex of 10, co-authored 11 publications receiving 2879 citations. Previous affiliations of Hanane Laklai include French Institute of Health and Medical Research & University of Toulouse.
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Journal ArticleDOI
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more
TL;DR: Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival, and underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.
Journal ArticleDOI
Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]
Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Raghu Kalluri +20 more
TL;DR: This research highlights the need to understand more fully the role of language in the development of post-traumatic stress disorder and the role that language can play in the recovery.
Journal ArticleDOI
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Hanane Laklai,Yekaterina A. Miroshnikova,Michael W. Pickup,Eric A. Collisson,Grace E. Kim,Alexander S. Barrett,Ryan C. Hill,Johnathon N. Lakins,David D. Schlaepfer,Janna K. Mouw,Valerie S. LeBleu,Nilotpal Roy,Sergey V. Novitskiy,Julia S. Johansen,Valeria Poli,Raghu Kalluri,Christine A. Iacobuzio-Donahue,Laura D. Wood,Matthias Hebrok,Kirk C. Hansen,Harold L. Moses,Valerie M. Weaver +21 more
TL;DR: The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors and highlight STAT3 and mechanics as key drivers of this phenotype.
Journal ArticleDOI
Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
TL;DR: Ciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression.
Journal ArticleDOI
Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-β–Deficient Mouse Mammary Carcinomas
Michael W. Pickup,Hanane Laklai,Irene Acerbi,Philip Owens,Agnieszka E. Gorska,Anna Chytil,Mary Aakre,Valerie M. Weaver,Harold L. Moses +8 more
TL;DR: Stromal expansion in PyMT(mgko) tumors is likely caused through the modulation of immune cell infiltrates to promote fibroblast activation, which feeds back to the epithelium to promote metastasis by modulating phenotypic characteristics of basal cells.