H
Hannu Järveläinen
Researcher at University of Turku
Publications - 57
Citations - 2949
Hannu Järveläinen is an academic researcher from University of Turku. The author has contributed to research in topics: Decorin & Extracellular matrix. The author has an hindex of 25, co-authored 56 publications receiving 2736 citations. Previous affiliations of Hannu Järveläinen include University of Tampere & University of Oulu.
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Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy
TL;DR: The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and noncollagenous glycoproteins, and this activity may in part be beneficial to the drugs' disease-modifying properties.
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Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.
TL;DR: The results indicate that although both of these growth factors increase the net synthesis of a large versican like CSPG, they differ in their effects on the structure of the glycosaminoglycan chains.
Journal Article
Smooth muscle cell expression of extracellular matrix genes after arterial injury.
TL;DR: The results support the conclusion that ECM gene expression is a relatively late event in the response of the carotid artery, and that some of the genes are expressed only in the intima whereas others are expressed in both the Intima and media.
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A role for decorin in cutaneous wound healing and angiogenesis
Hannu Järveläinen,Pauli Puolakkainen,Pauli Puolakkainen,Sari H. Pakkanen,Eric L. Brown,Magnus Höök,Renato V. Iozzo,E. Helene Sage,Thomas N. Wight +8 more
TL;DR: In this paper, a statistically significant delay in excisional wound healing in the Dcn(-/-) mice occurred at 4 and 10 days postwound and, in incisional wounds at 4, 10, and 18 days when compared with wild-type (Dcn)-controls.
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Platelet-derived growth factor and transforming growth factor-beta 1 differentially affect the synthesis of biglycan and decorin by monkey arterial smooth muscle cells.
TL;DR: It is indicated that PDGF and TGF-beta 1 have specific but different effects on the synthesis of small CS/DS PGs by monkey ASMCs in culture.