Hannu Koistinen

TL;DR: It is shown that, in adults, there is a substantial genetic contribution responsible for interindividual variation of the circulating levels of IGF-I, IGF-II, and IGFBP-3, but not for the IGF BP-1 levels.

TL;DR: The potent inhibitory effect of glycodelin on initial human sperm-zona pellucida binding is consistent with previous suggestion that this cell adhesion event requires a selectin-like adhesion process and raises the possibility that a convergence between immune and gamete recognition processes may have occurred in the types of carbohydrate ligands recognized in the human.

TL;DR: Along with being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of gly codelin cDNA into a glyCodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers.

TL;DR: It is concluded that insulin reduction with metformin increases follicular and luteal phase serum glycodelin and insulin-like growth factor-binding protein-1 concentrations and enhances lutesal phase uterine vascularity and blood flow in the polycystic ovary syndrome.

TL;DR: This study provides the first evidence for gender-specific glycosylation that may serve to regulate key processes involved in human reproduction and contribute to the immunosuppressive activity of human seminal plasma and to the low immunogenicity of sperm.