H
Hans Jürgen Machulla
Researcher at University of Tübingen
Publications - 18
Citations - 2858
Hans Jürgen Machulla is an academic researcher from University of Tübingen. The author has contributed to research in topics: Bone remodeling & Positron emission tomography. The author has an hindex of 11, co-authored 18 publications receiving 2742 citations.
Papers
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Journal ArticleDOI
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.
Anthony F. Shields,John R. Grierson,B M Dohmen,Hans Jürgen Machulla,J C Stayanoff,Jawana M. Lawhorn-Crews,Joyce E. Obradovich,Otto Muzik,Thomas J. Mangner +8 more
TL;DR: [F-18]FLT (3'-deoxy-3'-fluorothymidine) is developed and tested; it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects.
Journal ArticleDOI
Simultaneous PET-MRI: a new approach for functional and morphological imaging
Martin S. Judenhofer,Hans F. Wehrl,D.F. Newport,Ciprian Catana,Stefan Siegel,Markus Becker,Axel Thielscher,Manfred Kneilling,M. P. Lichy,Martin Eichner,Karin Klingel,Gerald Reischl,Stefan Widmaier,Martin Röcken,Robert E. Nutt,Hans Jürgen Machulla,Kamil Uludag,Simon R. Cherry,Claus D. Claussen,Bernd J. Pichler +19 more
TL;DR: This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI), and develops a three-dimensional animal PET scanner that is built into a 7-T MRI.
Journal Article
Hypoxia-Specific Tumor Imaging with 18F-Fluoroazomycin Arabinoside
Morand Piert,Hans Jürgen Machulla,Maria Picchio,Gerald Reischl,Sybille Ziegler,Piyush Kumar,Hans-Jürgen Wester,Roswitha Beck,Alexander J.B. McEwan,Leonard I. Wiebe,Markus Schwaiger +10 more
TL;DR: (18)F-FAZA shows superior biokinetics and is, thus, a promising PET tracer for the visualization of tumor hypoxia and also verified a Hypoxia-specific uptake mechanism for (18)f-FAza in murine tumor models.
Journal ArticleDOI
PET Imaging of Prostate Cancer Xenografts with a Highly Specific Antibody against the Prostate-Specific Membrane Antigen
Ursula Elsässer-Beile,Gerald Reischl,Stefan Wiehr,Patrick Bühler,Philipp Wolf,Karen Alt,John E. Shively,Martin S. Judenhofer,Hans Jürgen Machulla,Bernd J. Pichler +9 more
TL;DR: Because of the high and specific uptake of 64Cu-labeled mAb 3/A12 in PSMA-positive tumors, this ligand represents an excellent candidate for prostate cancer imaging and potentially for radioimmunotherapy.
Journal ArticleDOI
Central serotonin transporter levels are associated with stress hormone response and anxiety
Matthias Reimold,Astrid Knobel,Michael A. Rapp,Anil Batra,Klaus Wiedemann,Andreas Ströhle,A Zimmer,Peter Schönknecht,Michael N. Smolka,Daniel R. Weinberger,David Goldman,Hans Jürgen Machulla,Roland Bares,Andreas Heinz +13 more
TL;DR: The association between stress hormone response, thalamic 5-HTT levels, and anxiety in patients suffering from negative mood states suggests an interaction between two major mechanisms implicated in negative Mood states in humans.