Hans-Peter Lenhof

TL;DR: The data provide strong evidence for the relevance of circulating non-coding RNAs to detect Alzheimer’s from a blood sample.

TL;DR: Extended expression profiling by a novel statistical gene set enrichment identified pathways that have previously not been associated with meningioma that were significantly deregulated biochemical pathways using Kyoto encyclopedia of genes and genomes and Transpath databases.

TL;DR: By simultaneous targeting of 14 mRNAs miR-34a acts as major hub of T cell regulatory networks suggesting to utilize miR -34a as target of intervention towards a modulation of the immune responsiveness of T-cells in a broad tumor context.

TL;DR: Molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients and the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer.

TL;DR: This study systematically investigated the impact of three different permutation test approaches for over-representation analysis to detect false positive pathway candidates and evaluated them on genome-wide association data of Dilated Cardiomyopathy and Ulcerative Colitis to provide evidence that the gold standard - permuting the case–control status – effectively improves specificity of GWAS pathway analysis.